Objective:To explore the clinical significance of plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D) and thromboela-stogram (TEG) in judging the coagulation status for pregnant women. Methods:One hundred and sixty cases of pregnant women undergoing labor examination in Qionghai Maternal and Child Health Hospital were selected as observation group, another 80 healthy women without pregnancy were selected as control group. The results of three items of coagulation(PT,APTT,FIB), D-D test and TEG test of thetwo groups and the relationship between the three items of coagulation, D-D and TEG were analyzed. According to whether three items of coagulation, D-D and TEG parameters were normal or not, the pregnant women in the observation group were divided into abnormal group (at least two abnormalities were found in three items of coagulation, D-D and TEG parameters) and normal group, the relationship between three items of coagulation, D-D,TEG parameters and the incidence of venous thromboembolism, disseminated intravascular coagulation (DIC), premature rupture of membranes, postpartum hemorrhage, abnormal neonatal constitution, maternal death and neonatal death were analyzed. Results:PT and APTT in the observation group were shorter than those in the control group (all P<0.05), The coagulation reaction time (R value) and clot formation time (K value) of TEG in the observation group were lower than those in the control group (all P<0.05). The levels of FIB and D-D and the maximum amplitude (MA value)of TEG in the observation group were higher than those in the control group (all P<0.05). The R and K values of TEG were positively correlated with PT and APTT, but negatively correlated with FIB and D-D levels (all P<0.05). MA value of TEG was negatively correlated with PT and APTT, and positively correlated with FIB and D-D levels (P<0.05).Traditional routine coagulation test had good consistency with TEG test in evaluating hypercoagulability (Kappa value=0.812). The total incidence of vein embolism, DIC, premature rupture of membranes, postpartum hemorrhage, abnormal neonatal constitution, maternal death and neonatal death of theabnormal group were higher than those of the normal group (P<0.05). Conclusion:Combination of the three coagulation tests, D-D test and TEG test can help to scientifically evaluate the coagulation function of pregnant women, predict the pregnancy outcome of clinical pregnant women, and provide reference for the prevention and treatment of perinatal massive hemorrhage and DIC.
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