Objective:To investigate the expression of signal transduction and activator of transcription(STAT)3, STAT4 in peripheral blood mononuclear cells (PBMC)in children with bronchial asthma and its significance. Methods:Thirty-one children with bronchial asthma and 35 healthy children were selected as study subjects. Pulmonary function and fractional exhaled nitric oxide(FeNO)levels were recorded in both groups. Serum levels of interleukin(IL)-6, IL-12, and eosinophilic cells (EOS) were compared between the two groups. The expression of STAT3 mRNA and STAT4 mRNA in PBMC was analyzed. Results:Compared with the control group, the level of STAT4 mRNA in the asthmatic group was significantly lower and the STAT3 mRNAwas significantly higher in the asthmatic group (P<0.05). The expression of STAT3 mRNA was negatively correlated with lung function index and IL-12 level, and positively correlated with FeNO, EOS and IL-6level (all P<0.05). The expression of STAT4 mRNA was positively correlated with lung function index and IL-12level, and was negative correlated with FeNO,EOS and IL-6level (all P<0.05). Conclution:STAT3 and STAT4 are involved in the occurrence and progression of bronchial asthma in children and have a certain regulatory effect on airway inflammation in asthma. |