联合检测血清UA、CNTF、BDNF表达水平在评估急性脑卒中后抑郁患者预后中的价值-现代医学

联合检测血清UA、CNTF、BDNF表达水平在评估急性脑卒中后抑郁患者预后中的价值

单位：1. 承德医学院附属医院老年病科, 河北承德 067000;
2. 承德市中心医院重症医学科, 河北承德 067000;
3. 承德医学院附属医院放射科, 河北承德 067000

分类号：R447

出版年·卷·期（页码）：2019·47·第六期（697-700）

摘要：

目的：分析联合检测血清尿酸（UA）、睫状神经营养因子（CNTF）及脑源性神经营养因子（BDNF）表达水平在评估急性脑卒中后抑郁患者预后中的价值。方法：选取我院2016年1月至2018年1月收治100例急性脑卒中后抑郁患者作为观察组，100例急性脑卒中后无抑郁患者作为对照组，检测血中UA、CNTF、BDNF表达水平，以汉密顿抑郁量表作为金标准，分析各指标单独诊断及联合诊断的诊断效能。结果：观察组患者血中UA、CNTF及BDNF水平均明显低于对照组，且差异有统计学意义（P<0.05）；UA、CNTF及BDNF均是影响急性脑卒中后抑郁发生的独立性危险性因素（P<0.05）；平行联合诊断的阴性预测值、灵敏度高于单独应用（P<0.05），系列联合诊断的阳性预测值、特异度高于单独应用（P<0.05），且平行联合及系列联合诊断的ROC曲线下面积均显著高于各指标单独应用（P<0.05）。结论：联合检测血清UA、CNTF、BDNF表达水平有助于提高评估急性脑卒中后抑郁患者预后的灵敏度及特异度，值得在临床中推广应用。

Objective:To analyze the value of combined detection of serum uric acid (UA), ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in evaluating the prognosis of patients with acute post-stroke depression. Methods:100 patients with acute post-stroke depression were enrolledfrom January 2016 to January 2018. 100 patients with no depression after acute stroke were used as control group. The Hamilton Depression Scale was used as the gold. The standard was used to detect the expression levels of UA, CNTF and BDNF in blood, and to analyze the diagnostic efficacy of individual diagnosis and combined diagnosis. Results:The levels of UA, CNTF and BDNF in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). UA, CNTF and BDNF were the independent risks factors affecting post-stroke depression (P<0.05). The negative predictive value and sensitivity of the parallel combined diagnosis were higher than the single application, and the difference was statistically significant (P<0.05). The positive predictive value and specificity of the serial combined diagnosis were higher than the single application, and the difference was statistically significant (P<0.05), and the area under the ROC curve of the parallel combination and serial combination diagnosis was significantly higher than that of each index alone (P<0.05). Conclusion:The combined detection of serum UA, CNTF and BDNF expression levels can improve the sensitivity and specificity of evaluating the prognosis of patients with post-stroke depression. It is worthy of popularization in clinical practice.

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