血浆p38 MAPK、胃饥饿素水平与糖尿病患者胰岛素抵抗的相关性研究-现代医学

血浆p38 MAPK、胃饥饿素水平与糖尿病患者胰岛素抵抗的相关性研究

单位：国家电网公司北京电力医院内分泌科, 北京 100073

分类号：R587.1

出版年·卷·期（页码）：2019·47·第五期（579-582）

摘要：

目的：探讨血浆p38 MAPK、胃饥饿素水平与糖尿病患者胰岛素抵抗的相关性。方法：选取2016年10月至2017年12月本院收治的110例糖尿病患者作为糖尿病组，并选取同期在本院接受健康体检的110例正常人作为对照组。比较两组基本资料、生化指标，并进行Pearson相关分析和Logistic多元回归相关分析。结果：收缩压（SBP）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、p38 MAPK、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、胃饥饿素水平糖尿病组均显著高于对照组（P<0.05），高密度脂蛋白胆固醇（HDL-C）水平糖尿病组显著低于对照组（P<0.05）。SBP、TG、LDL-C、p38 MAPK、FPG、HbA1c、胃饥饿素、胰岛素抵抗指数水平肥胖糖尿病患者显著高于非肥胖患者（P<0.05），而HDL-C水平肥胖糖尿病患者显著低于非肥胖组患者（P<0.05）。经Pearson相关性分析，SBP、TG、LDL-C、p38 MAPK、FPG、HbA1c、胃饥饿素水平与胰岛素抵抗指数呈正相关，HDL-C水平与胰岛素抵抗指数呈负相关。经多元回归分析，p38 MAPK、胃饥饿素水平与胰岛素抵抗指数有关，是糖尿病患者胰岛素抵抗的独立影响因素。结论：p38 MAPK、胃饥饿素水平均与糖尿病患者胰岛素抵抗密切相关，且均为危险因素。

Objective:To investigate the relationship between p38 MAPK, ghrelin and insulin resistance in plasma for patients with diabetes. Methods:The clinical data of 110 patients with diabetes from October 2016 to December 2017 in our hospital were studied retrospectively.110 healthy persons were selected as control group. The basic data and biochemical indexes were compared between these two groups, and Pearson correlation analysis and logistic multivariate regression correlation analysis were carried out. Results:The levels of SBP, LDL-C, TG, p38 MAPK, FPG, HbA1c and ghrelin in patients with diabetes mellitus were significantly higher than those in the control group(P<0.05), and the level of HDL-Cin patients with diabetes mellitus was significantly lower than those in the control group(P<0.05).The levels of insulin resistance index, SBP, TG, p38 MAPK, FPG, LDL-C, HbA1c and ghrelin for obese patients in diabetes mellitus were significantly higher than those of non-obese subjects (P<0.05), but the level of HDL-C was significantly lower than those of non-obese subjects (P<0.05).Pearson correlation analysis showed that SBP, TG, LDL-C, p38 MAPK, FPG, HbA1c and ghrelin was positively correlated with insulin resistance index, while HDL-C was negatively correlated with insulin resistance index.Multivariate regression analysis showed that both p38 MAPK and ghrelin were associated with the insulin resistance index and they were independent risk factors of insulin resistance for diabetes. Conclusion:p38 MAPK, ghrelin are closely related to insulin resistance for diabetes, which are the risk factors.

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