Objective:To observe effect of the application of the uterine artery embolization with methotrexate artery perfusion in the treatment of mid-pregnancy induced labor of central type of placenta previa and the postoperative reactions of patients with different gestational age. Methods:From January 2015 to December 2017, 17 middle-term pregnant women with central placenta previa who were hospitalized in Nantong Maternal and Child Health Hospital were given uterine arterial embolization and 80 mg arterial infusion of methotrexate during the operation. 12 hours after operation, mifepristone tablets were given twice a day for 50 mg. Those who could not initiate uterine contraction at 24 hours were treated with forceps curettage on the 3rd day after operation for less than 17 weeks of pregnancy. After 17 weeks of pregnancy and more than 24 hours after operation, the labor was induced by injection of salmadine into amniotic cavity, and those who could not induce uterine contraction were given water sac and oxytocin for 3 days after induction of labor. Results:15 cases of vaginal labor were successful. The mean period of recovery of the chorionic gonadotropinwas (45.2±6.7) days, and the average time for the normal recovery of the chorionic gonadotropin was (22.5±13.7) days. The mean amount of blood loss was (267.7±195.2) ml in the course of induced labor.The amount of blood loss after operation was less than that in the group with cesarean section, and the difference was statistically significant (P<0.05). Conclusion:Uterine artery embolization can improve the success rate of vaginal delivery, reduce the ratio of caesarean section and hysterectomy, reduce the incidence of massive hemorrhage and improve the prognosis of placenta previa in the second trimester of pregnancy. At the same time, the longer the gestation week, the lower the success rate of vaginal induction, and the history of cesarean section is the risk factor of massive bleeding in induced labor, which needs to be paid attention to in clinical management.