Objective:To study the effect of serum procalcitonin (PCT), interleukin-6 (IL-6) and C-reactive protein (CRP) on the prognosis of patients with severe traumatic sepsis, and provide a basis for clinical diagnosis and treatment. Methods:Clinical data of 102 patients with severe trauma-induced sepsis treated in our hospital from November 2013 to May 2017 were retrospectively analyzed, and According to the survival conditions within 28 days after admission, they were divided into survival group with 57 patients and death group with 45 patients. Another 50 healthy blood donors were selected as control group. Inflammatory index, troponin I (cTnI), acute physiology and chronic health scores within 24 hours (APACHCE-Ⅱ), and Sequential Organ Failure Assessment (SOFA) scores within 24 hours were compared between the three groups. The effects of inflammation index, cTnI and APACHCE-Ⅱ, SOFA score, inflammation index and cTnI on the prognosis of patients were analyzed. Results:The PCT, IL-6, CRP, and cTnI in the control group were significantly lower than those in the survival group and the death group, and the differences were statistically significant (P<0.01).The APACHCE-Ⅱ and SOFA scores in the survival group were significantly lower than those in the death group. The differences were statistically significant (P<0.01). PCI, IL-6, CRP and cTnI were positively correlated with APACHCE-Ⅱ; PCI, IL-6 and CRP were positively correlated with SOFA score; cTnI was not correlated with SOFA score. The area under the curve of CRP evaluation for the prognosis of severe trauma-induced sepsis was significantly larger than that of PCT, IL-6 and cTnI, and the difference was statistically significant (P<0.05). Conclusion:PCT, IL-6 and CRP can effectively predict the prognosis of patients with severe trauma-induced sepsis, and the value of CRP judgment is greater.
 ANAND D,RAY S,BHARGAVA S,et al.Exploration of eosinopenia as a diagnostic parameter to differentiate sepsis from systemic inflammatory response syndrome:results from an observational study[J].Indian J Crit Care Med,2016,20(5):285-290.
 YILMAZ H,DURAN L,YANIK K,et al.Differences in the effectiveness of serum biomarkers for the diagnosis of bacterial infections in adult and elderly patients admitted to the emergency department[J].Turk J Med Sci,2015,45(3):553-557.
 LIU Y,YANG W,WEI J.Guiding effect of serum procalcitonin (PCT) on the antibiotic application to patients with sepsis[J].Iran J Public Health,2017,46(11):1535-1539.
 ZHANG L,ZHANG X.Serum sTREM-1,PCT,CRP,Lac as biomarkers for death risk within 28 days in patients with severe sepsis[J].Open Life Sci,2018,13(1):42-47.
 DEBIANE L,HACHEM R Y,Al WOHOUSH I,et al.The utility of proadrenomedullin and procalcitonin in comparison to C-reactive protein as predictors of sepsis and bloodstream infections in critically Ill patients with cancer[J].Crit Care Med,2014,42(12):2500-2507.