Objective:To explore the relationship between sleep disturbance and changes of melatonin level in patients with Parkinson's disease(PD). Methods:One hundred and seventeen patients with PD admitted to the Department of Neurology in our hospital were selected. All subjects were divided into two groups, i.e., sleep disturbance group(n=71) and non-sleep disturbance group(n=46),according to the score of Parkinson's disease sleep scale sleep(PDSS), and the illness state and levels of melatonin(MLT) on 6 time points were assessed and compared between the two groups by united Parkinson's disease rating scale(UPDRS)and Hoehn-Yahr staging and enzyme linked immunosorbent assay(ELISA). Multivariate Logistic Regression was used to analyze the factors influencing sleep disturbance in patients with PD. Results:(1)Each subscale score and total score in UPDRS were higher in sleep disturbance group than those in non-sleep disturbance group(P<0.01), and in Hoehn-Yahr staging, the ratio of Ⅲ staging was higher and the ratio of Ⅰ staging was lower in sleep disturbance group than those in non-sleep disturbance group respectively(P<0.05). (2)The serum MTL levels at 6:00, 10:00, 14:00, 18:00 were higher in sleep disturbance group than those in non-sleep disturbance group(P<0.01). (3)Multivariate Logistic Regression showed that UPDRS-Ⅲ score, UPDRS total score and serum MTL levels were risk factors for sleep disturbance in patients with PD(P<0.05). Conclusion:The serum MTL levels are higher in patients with PD, and MTL may be one of the factors leading to sleep disorders in PD patients.
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