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骨肉瘤患者微小RNA124的表达水平及其对预后的预测价值
作者:陈汉文  高书明  辛大森  程才  李勇 
单位:沧州市中心医院 骨一科, 河北 沧州 061001
关键词:骨肉瘤 微小RNA124 表达 预后 
分类号:R738.1
出版年·卷·期(页码):2019·47·第四期(394-397)
摘要:

目的:探究骨肉瘤患者微小RNA124(miR-124)的表达水平及其对预后的预测价值。方法:选择在我院手术治疗的86例骨肉瘤患者,根据miR-124水平分为高水平组(42例)和低水平组(44例),并选择20例新鲜骨折的患者作为对照组;比较3组患者miR-124的表达水平,分析高水平与低水平组患者临床资料及预后的差异,以及影响患者预后的危险因素。结果:低水平组患者的临床分期ⅡB/Ⅲ期、远处转移以及化疗效果不佳的比例显著高于高水平组(P<0.05)。骨肉瘤患者miR-124表达量显著低于对照组(P<0.05);骨肉瘤患者非肿瘤组织中miR-124表达量明显高于肿瘤组织(P<0.05)。高水平组患者的死亡风险明显低于低水平组(HR=0.463,P=0.029)。Cox回归分析显示,miR-124低表达是患者预后不佳的独立危险因素(HR=2.145,P=0.044),化疗有效是保护因素(HR=0.495,P=0.047)。结论:骨肉瘤患者miR-124表达水平较低,miR-124低表达水平患者的预后较差;化疗有效是骨肉瘤患者术后预后的保护因素,miR-124低表达是独立危险因素。

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