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咪唑啉I2受体生物学功能研究进展
作者:朱娅娜  席宏杰  薛辛辛  张茹茹 
单位:哈尔滨医科大学附属第二医院 麻醉科, 黑龙江 哈尔滨 150086
关键词:咪唑啉I2受体 抗伤害感受性作用 神经保护 2-BFI 综述 
分类号:Q7
出版年·卷·期(页码):2019·47·第三期(354-357)
摘要:

本综述总结归纳了咪唑啉I2受体生物学功能研究的最新进展。咪唑啉I2受体配体是探讨与I2受体有关的药理作用的一种非常有价值的研究工具,大量证据提示咪唑啉I2受体配体本身具有抗伤害感受性作用,并且与镇痛药的联合使用不仅增强镇痛药的抗伤害性感受性作用,还可以减轻长期使用镇痛药产生的耐受性和依赖性等副作用。咪唑啉I2受体配体的另一作用是具有确切的神经保护作用,但其具体机制需要进一步探索及研究。此外,一些研究表明咪唑啉I2受体具有改善阿尔兹海默病、抗抑郁、调节体温等作用。

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