长链非编码RNA在肿瘤的发生发展中起到重要的作用。随着研究深入，发现在神经母细胞瘤中表达的长链非编码RNA核内小RNA宿主基因16（SNHG16）在多种肿瘤细胞中存在异常表达现象。越来越多的研究指出，SNHG16对肿瘤细胞的增殖、凋亡及迁移有影响。因此，SNHG16可能与肿瘤诊断和预后有重要关系，并有希望成为药物治疗的新靶点。作者结合国内外研究报道，就SNHG16在相关肿瘤的发生发展过程中的作用及其机制进行综述。

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