Objective:To investigate the curative effect of levosimendan combined with torsemide used in patients with heart failure caused by dilated cardiomyopathy. Methods:A total of 164 patients with heart failure caused by dilated cardiomyopathy admitted to our hospital from May 2016 to May 2018 were randomly divided into observation group (group A, 82 cases) and control group (group B, 82 cases). Both of the groups were treated with conventional drugs, and patients of group B was treated with torasemide. Base on that, patients of group A was treated with levosimendan. The analysis of two groups of six minute walk test(6 MWT), left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), left ventricular end-diastolic diameter(LVEDD), serum troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide(NT-proBNP), and adverse reactions were compared.Results:After treatment, the cardiac function indexes in both groups were significantly improved.Compared with group B, patients in group A showed significantly lower levels of LVESD, LVEDD, cTnI, NT-proBNP(P<0.05), 6MWT distance significantly increased(P<0.05), LVEF significantly increased(P<0.05).During the treatment, the type and frequency of adverse reactions in group B were significantly higher than those in group A(P<0.05). Conclusion:Levosimendan combined with torasemide is effective in heart failure patients caused by dilated cardiomyopathy, and has a certain clinical value in reducing the occurrence of adverse reactions. |
[1] 谢印军.R波递增不良与扩张型心肌病左室逆重构、Tei指数及N-端脑钠肽前体的关系[J].现代医学,2017,45(2):220-223.
[2] 陶建平,魏盟,陈忠.KIM-1在扩张型心肌病心力衰竭患者中肾功能的评估作用[J].现代医学,2016,44(9):1278-1281.
[3] 魏文佳.动态心电图在扩张型心肌病植入心室同步化起搏电复律除颤器后的应用研究[J].现代医学,2016,44(4):508-511.
[4] 李丹,刘凤岐,周晋.高位硬膜外阻滞治疗心脏瓣膜病心力衰竭的疗效观察[J].东南大学学报(医学版),2016,35(2):183-185.
[5] 张颖雪,赵新湘.扩张型心肌病左心结构功能心脏磁共振评价与NT-proBNP相关性研究[J].中国临床医学影像杂志,2018,29(6):404-408.
[6] 张燕,王文生,廉静.参附注射液联合磷酸肌酸钠治疗扩张型心肌病心功能不全效果[J].精准医学杂志,2018,33(3):256-258,262.
[7] 程妍.倍他乐克用于治疗扩张型心肌病的效果评价[J].中国医药指南,2018,16(15):136-137.
[8] 王宇竞,敖敏高娃.糖原磷酸化酶同工酶脑型:心肌损伤的新标志物[J].医学综述,2011,17(2):175-177.
[9] 杜金勇,王功勋.托拉塞米序贯治疗对冠心病致慢性心衰心功能的影响[J].现代临床医学,2016,42(1):31-33.
[10] 陈勇鹏,王银波,王博东.黄芪颗粒联合贝那普利治疗扩张型心肌病合并心力衰竭的临床疗效[J].中国现代药物应用,2018,12(9):1-3.
[11] 薄小萍,李明秋,陈茂华.重组人脑利钠肽治疗急性心梗后失代偿性心力衰竭的疗效观察[J].东南大学学报(医学版),2012,31(1):93-96.
[12] 王江友,陈涵,鄢华.左西孟旦对猪冠状动脉微栓塞后心肌细胞凋亡的影响[J].中华老年心脑血管病杂志,2018,20(1):78-82.
[13] 顾方方,程震锋.左西孟旦联合中药治疗扩张型心肌病伴心力衰竭临床研究[J].中华中医药学刊,2017,35(10):2634-2637.
[14] 李洪芹,刘帅,胡学军.托拉塞米治疗终末期扩张型心肌病的疗效观察[J].临床合理用药杂志,2016,9(14):25-26.
[15] KIVIKKO M,LEHTONEN L.Levosimendan:a new inodilatory drug for the treatment of decompensated heart failure[J].Current Pharmaceutical Design,2005,11(4):135-137.
[16] ERB J,BEUTLHAUSER T,FELDHEISER A,et al.Influence of levosimendan on organ dysfunction in patients with severely reduced left ventricular function undergoing cardiac surgery[J].Journal of International Medical Research,2014,42(3):750-764. |