Objective:To investigate the correlation between oxidative stress and neurological function scores, and neurological recovery in patients with ischemic stroke. Methods:60 patients with ischemic stroke admitted to our hospital from December 2016 to December 2017 and 60 healthy subjects underwent physicalexamination in the same period were enrolled in this study. The objects were divided into the disease group and the control group.The levels of serum superoxide dismutase(SOD), total antioxidant capacity(TAC) and malondialdehyde(MDA) were compared between the two groups. The correlation between SOD, TAC, MDA and neurological impairment score (NIHSS) was analyzed by linear regression. The correlation between SOD, TAC, MDA and neurological recovery was analyzed by ROC curve.Results:The levels of SOD and TAC of the disease group were significantly lower than those of the control group (P<0.05). The level of MDA of the disease group was higher than that of the control group (P<0.05). The correlation analysis between SOD, TAC, MDA and NHISS scores showed that SOD was negatively correlated with NIHSS score (r=-0.873, P=0.000), and there was a negative correlation between TAC and NHISS score (r=-0.792, P=0.000).), and there was a positive correlation between MDA and NHISS score (r=0.868, P=0.000). After treatment, the levels of SOD and TAC increased and the level of MDA decreased. Compared with prognosis of neurological function improvement, the area under the SOD ROC curve was 0.722, 95% CI:0.596-0.849, P=0.008; the area under the TAC ROC curve was 0.690, 95% CI:0.561-0.818, P=0.023; the area under the MDA ROC curve was 0.832, 95% CI:0.729-0.935, P=0.000. Conclusion:There is abnormal oxidative stress in patients with ischemic stroke. The presence of SOD, TAC and MDA is significantly correlated with the degree of neurological impairment and recovery of neurological function. The prognosis of patients with ischemic stroke can be predicted by SOD, TAC and MDA levels.
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