Objective:To investigate the correlation between oxidative stress and neurological function scores, and neurological recovery in patients with ischemic stroke. Methods:60 patients with ischemic stroke admitted to our hospital from December 2016 to December 2017 and 60 healthy subjects underwent physicalexamination in the same period were enrolled in this study. The objects were divided into the disease group and the control group.The levels of serum superoxide dismutase(SOD), total antioxidant capacity(TAC) and malondialdehyde(MDA) were compared between the two groups. The correlation between SOD, TAC, MDA and neurological impairment score (NIHSS) was analyzed by linear regression. The correlation between SOD, TAC, MDA and neurological recovery was analyzed by ROC curve.Results:The levels of SOD and TAC of the disease group were significantly lower than those of the control group (P<0.05). The level of MDA of the disease group was higher than that of the control group (P<0.05). The correlation analysis between SOD, TAC, MDA and NHISS scores showed that SOD was negatively correlated with NIHSS score (r=-0.873, P=0.000), and there was a negative correlation between TAC and NHISS score (r=-0.792, P=0.000).), and there was a positive correlation between MDA and NHISS score (r=0.868, P=0.000). After treatment, the levels of SOD and TAC increased and the level of MDA decreased. Compared with prognosis of neurological function improvement, the area under the SOD ROC curve was 0.722, 95% CI:0.596-0.849, P=0.008; the area under the TAC ROC curve was 0.690, 95% CI:0.561-0.818, P=0.023; the area under the MDA ROC curve was 0.832, 95% CI:0.729-0.935, P=0.000. Conclusion:There is abnormal oxidative stress in patients with ischemic stroke. The presence of SOD, TAC and MDA is significantly correlated with the degree of neurological impairment and recovery of neurological function. The prognosis of patients with ischemic stroke can be predicted by SOD, TAC and MDA levels. |
[1] SOMMER C J.Ischemic stroke:experimental models and reality[J].Acta Neuropathol,2017,133(2):245-261.
[2] BENASSI B,FANCIULLI M,FIORENTINO F,et al.c-Myc phosphorylation is required for cellular response to oxidative stress[J].Mol Cell,2016,21(4):509-519.
[3] 中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[4] 刘盈盈,易兴阳,蔡招辉.急性脑卒中患者早期神经功能恶化的评估及改良Rankin评分的随访[J].中国社区医师,2017,33(30):34-35.
[5] 黄文龙,谢小华.脑卒中特异性神经功能缺损程度评估量表的研究进展[J].广东医学,2018,39(S1):305-308.
[6] MBABUIKE N,GASSIE K,BROWN B,et al.Revascularization of tandem occlusions in acute ischemic stroke:review of the literature and illustrative case[J].Neurosurg Focus,2017,42(4):15-17.
[7] MEHTA A,MAHALE R,BUDDARAJU K,et al.Intravenous thrombolysis for acute ischemic stroke:review of 97 patients[J].Journal of Neurosciences in Rural Practice,2017,8(1):38-40.
[8] GERSCHENFELD G,MURESAN I P,BLANC R,et al.Two paradigms for endovascular thrombectomy after intravenous thrombolysis for acute ischemic stroke[J].JAMA Neurol,2017,74(5):549-551.
[9] 何菊芳,李婷婷,孙晓运,等.氧化应激及炎性反应与缺血性脑卒中的关系[J].武警医学,2016,27(12):1234-1236.
[10] TIAN X,HE W,RONG Y,et al.Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress:involvement of mitochondrial function and biogenesis[J].J Biomed Sci,2017,24(1):38-40.
[11] MILANLIOGLU A,ASLAN M,OZKOL H,et al.Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke:influence on neurological status and outcome[J].Wien Klin Wochenschr,2015,128(5-6):169-174.
[12] 柴青,张可贤,唐育民,等.远端缺血预处理及创伤预处理对缺血再灌注损伤心肌的保护作用及抗氧化能力的比较[J].东南大学学报(医学版),2018,37(2):147-150.
[13] 吴志宝,孙国柱,孙博宇,等.氧化应激在大鼠液压冲击性脑损伤中的时程变化和意义[J].脑与神经疾病杂志,2016,24(12):727-730.
[14] 杨玮春,胡敏予.高脂血症与脑损伤、脑神经递质的研究进展[J].中国动脉硬化杂志,2017,25(9):948-952. |