Objective:To study the clinicopathologic features,diagnosis and differential diagnosis of hepatic epithelioid angiomylipoma (EAML). Methods:The routine HE staining and immunohistochemical method were used to analyze the cases andthe relevant literatures were reviewed. Results:Five patients ranged in age from 30 to 71 years old. Three casesoccurred in the right lobe of liver. One case in the left lobe of liver and one case in the hilar area.Five patients were performed surgical resection and one of them waslocal recurrence. EAML tended to be large,ranged in size from 3.6 cm to 12.0 cm.The cut surface was solid and pale brown. Microscopically, the tumors were predominantly composed of epithelioid cells, which were arranged in the shape of diffuse sheet, trabecular or nodular. The epithelioid cells were full of abundant eosinophilic cytoplasm. Partially transparent cells,obvious cellular atypia and nucleolus were seen. The proportion of epithelioid cells was 60%-90%. Immunohistochemical study showed that tumor cells were positive for HMB-45 and Melan-A, different degrees of expression of SMA, while CK, S100, CD34, Glypican-3 and hepatocyte were negative. Conclusion:Hepatic EAML is a potential malignant mesenchymal tumor, clinical manifestations and imaging changes are lack of specificity and easy to be misdiagnosed. Diagnosis depends on pathological examination and immunohistochemical detection. Because it may be transformed into malignant, the long-term close follow-up after operation is needed.