Objective:To observe the effect of beclomethasone dipropionate combined with montelukast on airway inflammation control and peripheral blood IgG 4 and ICAM-1 levels in patients with cough variant asthma.Methods:120 patients with cough variant asthma were enrolled in the study by convenient sampling. The subjects were divided into control group and study group with 60 cases in each group by random number table method. The control group was treated with beclomethasone dipropionate, and the study group was treated with montelukast sodium based on the control group, The patients in the two groups were treated continuously for 12 weeks. The success rate and relapse rate of patients in the study group and the experimental group were compared, and the levels of serum interleukin (IL-5,IL-8) and interleukin (IL-10) were analyzed before and after treatment. Changes of peripheral blood immunoglobulin 4 (IgG 4), intercellular adhesion molecule-1 (ICAM-1) and bronchodiastolic test.Results:The control rate of asthma in the study group was better than that in the control group (75.00% vs 50.00%), and the difference was statistically significant (χ2/4.658%, P<0.031). After treatment, the levels of IL-5,IL-8,IL-10 and TNF-α in the study group were significantly lower than those in the control group (P<0. 05). After treatment, the serum IgG 4 level and ICAM-1 level in the study group were higher than those in the control group, respectively (P<0.01). After 3 months follow-up, 11 cases (18.33%) recurred in the control group and 2 cases (3.33%) in the study group. The difference between the two groups was statistically significant (χ2, 6.98 8, P<0.008).Conclusion:Fluticasone propionate combined with montelukast sodium is effective in the treatment of cough variant asthma and can effectively reduce the levels of inflammatory factors and ICAM-1. It also has a great effect on raising the level of IgG 4. It is worth popularizing and applying.
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