Objective:To investigate the relationship between endoplasmic reticulum stress protein(CHOP-10), soluble intercellular adhesion molecule(sICAM-1) and vascular endothelial cell damage in patients with coronary heart disease.Methods:108 patients with coronary heart disease admitted in our hospital from January 2017 to February 2018 were classified into AMI, UAP and SAP group. 50 cases of healthy physical examination were selected as the control group at the same time. The basic data, vascular endothelial cell damage index, CHOP-10, sICAM-1, and Pearson correlation analysis and logistic regression analysis were compared in each group.Results:There was no significant difference in sex ratio, age, hypertension, diabetes, TG, FPG, Cr, UA in the four groups of subjects(P>0.05). The patients with coronary heart disease had significantly higher TC, LDL-C, Gensini, CHOP-10, sICAM-1, ET-1 and vWF than those in the control group. Sini integral, CHOP-10, sICAM-1, ET-1 and vWF were significantly higher than those in UAP group and SAP group, HDL-C and NO were significantly lower than those in UAP group and SAP group(NO). The scores of TC, LDL-C, Gensini, CHOP-10, sICAM-1, ET-1 and vWF in group UAP were significantly higher than those in SAP group, and HDL-C and NO were significantly lower than those in group A. CHOP-10 and sICAM-1 were negatively correlated with NO, while CHOP-10 and sICAM-1 were positively correlated with ET-1 and vWF. Logistic regression analysis showed that CHOP-10 and sICAM-1 were independent risk factors for endothelial dysfunction in coronary heart disease.Conclusion:The levels of sICAM-1 and CHOP-10 may promote the atherosclerosis process and aggravate the disease by inducing vascular endothelial dysfunction in patients with coronary heart disease.
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