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内质网应激蛋白、可溶性细胞间黏附分子与冠心病患者血管内皮细胞损伤的相关性
作者:黄为俊1  张帆2  李同社1  李艺乐3 
单位:1. 河南科技大学临床医学院/河南科技大学第三附属医院 心血管内科, 河南 洛阳 471003;
2. 河南科技大学临床医学院/河南科技大学第三附属医院 消化内科, 河南 洛阳 471003;
3. 河南科技大学临床医学院/河南科技大学第三附属医院 眼科, 河南 洛阳 471003
关键词:内质网应激蛋白 可溶性细胞间黏附分子 冠心病 血管内皮细胞损伤 
分类号:R541.4
出版年·卷·期(页码):2019·47·第二期(145-149)
摘要:

目的:探讨内质网应激蛋白(CHOP-10)、可溶性细胞间黏附分子(sICAM-1)与冠心病患者血管内皮细胞损伤的相关性。方法:选取2017年1月~2018年2月我院收治的108例冠心病患者进行研究。选取同期健康体检者50例作为对照组。比较各组患者基础资料、血管内皮细胞损伤指标、CHOP-10、sICAM-1,以及各指标间的Pearman相关性分析和Logistic回归分析。结果:4组研究对象的性别比例、年龄、高血压、糖尿病、TG、FPG、Cr、UA均无统计学差异(P>0.05);冠心病组患者TC、LDL-C、Gensini积分、CHOP-10、sICAM-1、ET-1、vWF显著高于对照组,HDL-C、NO显著低于对照组(P>0.05);AMI组患者TC、LDL-C、Gensini积分、CHOP-10、sICAM-1、ET-1、vWF显著高于UAP组和SAP组,HDL-C、NO显著低于UAP组和SAP组(P>0.05)。UAP组患者TC、LDL-C、Gensini积分、CHOP-10、sICAM-1、ET-1、vWF显著高于SAP组,HDL-C、NO显著低于SAP组(P>0.05)。CHOP-10、sICAM-1与NO呈负相关,CHOP-10、sICAM-1与ET-1、vWF呈正相关。经过Logistic回归分析,CHOP-10、sICAM-1是冠心病内皮功能损伤的独立危险因素。结论:sICAM-1和CHOP-10水平可能通过引起冠心病患者血管内皮功能损伤,促进动脉粥样硬化过程,加剧病情。

Objective:To investigate the relationship between endoplasmic reticulum stress protein(CHOP-10), soluble intercellular adhesion molecule(sICAM-1) and vascular endothelial cell damage in patients with coronary heart disease.Methods:108 patients with coronary heart disease admitted in our hospital from January 2017 to February 2018 were classified into AMI, UAP and SAP group. 50 cases of healthy physical examination were selected as the control group at the same time. The basic data, vascular endothelial cell damage index, CHOP-10, sICAM-1, and Pearson correlation analysis and logistic regression analysis were compared in each group.Results:There was no significant difference in sex ratio, age, hypertension, diabetes, TG, FPG, Cr, UA in the four groups of subjects(P>0.05). The patients with coronary heart disease had significantly higher TC, LDL-C, Gensini, CHOP-10, sICAM-1, ET-1 and vWF than those in the control group. Sini integral, CHOP-10, sICAM-1, ET-1 and vWF were significantly higher than those in UAP group and SAP group, HDL-C and NO were significantly lower than those in UAP group and SAP group(NO). The scores of TC, LDL-C, Gensini, CHOP-10, sICAM-1, ET-1 and vWF in group UAP were significantly higher than those in SAP group, and HDL-C and NO were significantly lower than those in group A. CHOP-10 and sICAM-1 were negatively correlated with NO, while CHOP-10 and sICAM-1 were positively correlated with ET-1 and vWF. Logistic regression analysis showed that CHOP-10 and sICAM-1 were independent risk factors for endothelial dysfunction in coronary heart disease.Conclusion:The levels of sICAM-1 and CHOP-10 may promote the atherosclerosis process and aggravate the disease by inducing vascular endothelial dysfunction in patients with coronary heart disease.

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