Objective:To investigate the clinical value of autoimmune antibody detection in patients with chronic hepatitis B.Methods:A total of 102 patients with chronic hepatitis B who were admitted during March 2014 and March 2017 were selected as observation group,another 102 patients who receivedphysical examination during the same period were selected as control group.The two groups of autoimmune antibodies were tested andliver function, liver fibrosis indexes and cytokines levels were compared between autoimmune antibody positive and negative patients in the observation group.Results:The total positive rate of autoimmune antibodies in the observation group was 26.47%, compared with 3.92% in the control group,the difference being statistically significant(P<0.05).In the observation group, the levels of aspartate aminotransferase(AST) and alanine aminotransferase(ALT) in autoimmune antibody positive patients were significantly higher than those in the negative patients, and the total protein(TP) and albumin(ALB) levels were significantly lower than those in negative patients,the difference being statistically significant(P<0.05).The levels of hyaluronidase(HA), laminin(LN), type Ⅲ procollagen(PCⅢ), and type IV collagen(IV-C) in autoimmune antibody positive patients were significantly higher than those in the negative patients with statistically significant differences(P<0.05).The levels of interleukin-4(IL-4), interleukin-6(IL-6) and interleukin-10(IL-10) in autoimmune antibody positive patients were significantly higher than those in negative patients,and Interferon-γ(IFN-γ) was significantly lower than those in the negative patients, and the difference was statistically significant(P<0.05). Conclusion:Autoimmune antibodies exist in patients with chronic hepatitis B, which have a certain effect on liver fibrosis index and related cytokines. The detection of autoimmune antibodies in patients with chronic hepatitis B can provide reference for the evaluation of the condition and the judgement of prognosis.
 JEARN L H,KIM T Y.The antiribosomal P antibodies really elicit autoimmune hepatitis?[J].Liver Int,2014,34(1):165-166.