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血清F-PSA、PSA、HGH、CA15-3水平与乳腺癌术后转移的相关性
作者:雷巧  陈俊杰  田建 
单位:江油市九○三医院 检验科, 四川 江油 621700
关键词:乳腺癌 术后转移 游离型前列腺特异性抗原 前列腺特异性抗原 人生长激素 糖类抗原15-3 
分类号:R737.9
出版年·卷·期(页码):2019·47·第一期(42-44)
摘要:

目的:探讨血清游离型前列腺特异性抗原(F-PSA)、前列腺特异性抗原(PSA)、人生长激素(HGH)、糖类抗原15-3(CA15-3)水平与乳腺癌术后转移的相关性。方法:选取我院收治的100例乳腺癌患者,治疗前检测患者血清F-PSA、PSA、HGH及CA15-3基线水平,行手术+辅助化疗和放疗后随访7~24个月,比较转移组和未转移组患者的血清F-PSA、PSA、HGH及CA15-3水平。结果:术后最长随访24个月,100例患者中术后转移44例,无转移56例,转移发生率为44%。乳腺癌术后转移组血清F-PSA、PSA、HGH及CA15-3水平高于未转移组,差异有统计学意义(P<0.05)。与各单项检测比较,F-PSA、PSA、HGH及CA15-3联合检测对预测乳腺癌术后转移的敏感性、特异性、准确性、阳性预测值、阴性预测值均升高(P<0.05)。结论:血清F-PSA、PSA、HGH及CA15-3可作为预测乳腺癌术后转移的重要肿瘤标志物。

Objective:To investigate the correlation between serum free prostate specific antigen (F-PSA), prostate specific antigen (PSA), human growth hormone (HGH) and carbohydrate antigen 15-3 (CA15-3) levels and postoperative metastasis in patients with breast cancer. Methods: One hundred cases of breast malignant tumors admitted to our hospital were enrolled in this study. The levels ofserum F-PSA, PSA, HGH and CA15-3 were measured before treatment. The patients were followed-up for 7 to 24 months after surgery-assisted chemotherapy and radiotherapy. The levels of serum F-PSA, PSA, HGH and CA15-3were compared between patients in the metastatic group and in the non-metastatic group. Results:There were 44 patients with postoperative metastases and 56 patients without postoperative metastases during the longest follow-up of 24 months after operation, and the incidence of metastasis was 44%. The levels of serum F-PSA, PSA, HGH and CA15-3 in the postoperative metastasis group were higher than those in the non-metastasis group (P<0.05). Compared with each individual test, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of combined detection of F-PSA, PSA, HGH and CA15-3 in predicting breast cancer metastasis after operation increased. Conclusion: The serum F-PSA,PSA,HGH and CA15-3 can be used as important tumor markers for predicting postoperative metastasis of breast cancer.

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