血清F-PSA、PSA、HGH、CA15-3水平与乳腺癌术后转移的相关性-现代医学

血清F-PSA、PSA、HGH、CA15-3水平与乳腺癌术后转移的相关性

单位：江油市九○三医院检验科, 四川江油 621700

关键词：乳腺癌术后转移游离型前列腺特异性抗原前列腺特异性抗原人生长激素糖类抗原15-3

分类号：R737.9

出版年·卷·期（页码）：2019·47·第一期（42-44）

摘要：

目的：探讨血清游离型前列腺特异性抗原（F-PSA）、前列腺特异性抗原（PSA）、人生长激素（HGH）、糖类抗原15-3（CA15-3）水平与乳腺癌术后转移的相关性。方法：选取我院收治的100例乳腺癌患者，治疗前检测患者血清F-PSA、PSA、HGH及CA15-3基线水平，行手术+辅助化疗和放疗后随访7～24个月，比较转移组和未转移组患者的血清F-PSA、PSA、HGH及CA15-3水平。结果：术后最长随访24个月，100例患者中术后转移44例，无转移56例，转移发生率为44%。乳腺癌术后转移组血清F-PSA、PSA、HGH及CA15-3水平高于未转移组，差异有统计学意义（P<0.05）。与各单项检测比较，F-PSA、PSA、HGH及CA15-3联合检测对预测乳腺癌术后转移的敏感性、特异性、准确性、阳性预测值、阴性预测值均升高（P<0.05）。结论：血清F-PSA、PSA、HGH及CA15-3可作为预测乳腺癌术后转移的重要肿瘤标志物。

Objective:To investigate the correlation between serum free prostate specific antigen (F-PSA), prostate specific antigen (PSA), human growth hormone (HGH) and carbohydrate antigen 15-3 (CA15-3) levels and postoperative metastasis in patients with breast cancer. Methods: One hundred cases of breast malignant tumors admitted to our hospital were enrolled in this study. The levels ofserum F-PSA, PSA, HGH and CA15-3 were measured before treatment. The patients were followed-up for 7 to 24 months after surgery-assisted chemotherapy and radiotherapy. The levels of serum F-PSA, PSA, HGH and CA15-3were compared between patients in the metastatic group and in the non-metastatic group. Results:There were 44 patients with postoperative metastases and 56 patients without postoperative metastases during the longest follow-up of 24 months after operation, and the incidence of metastasis was 44%. The levels of serum F-PSA, PSA, HGH and CA15-3 in the postoperative metastasis group were higher than those in the non-metastasis group (P<0.05). Compared with each individual test, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of combined detection of F-PSA, PSA, HGH and CA15-3 in predicting breast cancer metastasis after operation increased. Conclusion: The serum F-PSA,PSA,HGH and CA15-3 can be used as important tumor markers for predicting postoperative metastasis of breast cancer.

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