网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
冠状动脉内超选择应用替罗非班在STEMI患者PCI治疗中的应用价值
作者:李文强  余宏斌  朱洪斌  刘前君 
单位:重庆市开州区人民医院 心血管内科, 重庆 405400
关键词:超选择冠状动脉 介入治疗 急性ST段抬高型心肌梗死 临床价值 
分类号:R541.4
出版年·卷·期(页码):2019·47·第一期(17-20)
摘要:

目的:研究冠状动脉内超选择应用替罗非班在急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)中的应用价值。方法:筛选2015年6月至2016年12月期间于我院接受介入治疗的STEMI患者296例,采取随机数字表法分为超选择冠状动脉给药组(A组,91例)、常规冠状动脉给药组(B组,98例)和常规静脉给药组(C组,107例)。比较3组的心肌梗死溶栓后血流分级、ST段抬高回落率及随访3个月内相关临床不良事件的发生率。结果: 3组患者PCI术后TIMI血流分级Ⅲ级率差异有统计学意义(P<0.05),由高至低排列为C组 > B组 > A组;ST段完全回落率A组显著大于B、C组(P<0.05),B、C组之间ST段完全回落率差异无统计学意义(χ2=0.002,P>0.05);术后随访期间,A组相关临床不良事件的发生率明显低于B、C组(P<0.05),而B、C组相关临床不良事件发生率差异无统计学意义(χ2=1.003,P>0.05)。结论:在STEMI患者PCI中,冠状动脉内超选择应用替罗非班可以明显改善冠脉循环,减少术后相关临床不良事件的发生。

Objective: To study the application values of tirofiban utraselection percutaneous coronary intervention(PCI) in patients with ST segment elevation myocardial infarction (STEMI). Methods: A total of 296 patients with STEMI who were treated in our hospital from June 2015 to December 2016 were screened.Using random number table method, the patients were devided into 3 groups:91 patients(group A) were treated with ultraselective coronary artery administration, 91 patients(group B) were treated with conventional coronary artery administration (B group), and 107 patients(group C) were given conventional intravenous administration.The myocardial infarction thrombolytic blood flow classification,ST segment elevation drop rate and the incidence of adverse cardiovascular events during follow-up of3 months were compared among the three groups. Results: There were significant differences in TIMI grade Ⅲ rates of the three groups after PCI,from high to low was group C>group B> group A (P<0.05).The complete regression rate of ST segment of the group A was significantly higher than those of group B and group C(P<0.05), butthere was no significant difference between group B and group C (χ2=0.002, P>0.05).During the follow-up period, the incidence of related clinical adverse events was significantly lower in the group A than the other two groups(P<0.05),while there was no significant difference between the group B and group C (χ2=1.003, P>0.05). Conclusions: The effect of tirofiban utraselection PCI on patients with acute STEMI can significantly improve cardiac function, and reduce the occurrence of postoperative clinical adverse events.

参考文献:

[1] 张健发,刘婕,黄定.PCI术中联合使用腺苷与盐酸替罗非班对老年急性ST段高型心肌梗死心肌微循环及心功能的影响[J].中国老年学杂志,2014,34(12):3231-3233.
[2] 张在勇,张稳柱,宋明才,等.血栓抽吸结合血栓部位注射替罗非班在急诊PCI中的应用[J].临床心血管病杂志,2014,30(5):384-387.
[3] 汤成春,鞠成伟,李拥军,等.ThrombusterⅡ血栓抽吸导管联合冠脉内替罗非班对急性ST段抬高心肌梗死直接介入治疗预后的影响[J].江苏医药,2013,39(13):557-1559.
[4] 苏少辉,叶健烽,何小萍,等.急性心肌梗死患者冠脉内超选择应用替罗非班预防慢血流的临床研究[J].中外医疗,2014,33(21):98-99.
[5] 颜红兵,霍勇.急性冠状动脉综合征:认清本质指导实践[J].中国介入心脏病学杂志,2014,22(21):1-3.
[6] AKPEK M,SAHIN O,SARLI B,et al.Acute effects of intracoronary tirofiban on no-reflow phenomena in patients with ST-segment elevated myocardial infarction undergoing primary percutaneous coronary intervention[J].Angiology,2015,66(6):560-567.
[7] 苏少辉,叶健烽,何小萍,等.急性心肌梗死患者冠状动脉内超选择应用替罗非班的临床研究[J].中华老年医学杂志,2015,34(7):732-735.
[8] WANG Y,LI T,LIU Y,et al.Ischemic postconditioning before percutaneous coronary intervention for acute ST-segment elevation myocardial infarction reduces contrast-induced nephropathy and improves long-term prognosis[J].Arch Med Res,2016,47(6):483-488.
[9] PUDDU P E,SCHIARITI M,CUTURELLO D,et al.Kidney dysfunction and long-term outcome in post-PCI acute coronary syndrome patients treated by high-dose tirofiban:the role of creatinine clearance[J].Br J Med Med Res,2013,3(4):897.
[10] 唐良秋,梁家荣,陈云宪,等.超选择冠脉内注射替罗非班联合血栓抽吸对急性ST段抬高型心肌梗死患者心肌灌注的影响[J].中国心血管病研究杂志,2015(12):1123-1126.
[11] 任琳,王文广,王倩,等.半量替罗非班在老年急性心肌梗死急诊经皮冠状动脉介入治疗的疗效和安全性[J].中华老年心脑血管病杂志,2014,29(1):32-35.
[12] KASSAIAN S E,FATHI Y,LOTFI-TOKALDANY M,et al.Comparison of 1-year major adverse cardiac events in patients undergoing primary percutaneous coronary intervention receiving intracoronary bolus only versus intracoronary bolus plus infusion of glycoprotein Ⅱb/Ⅲa inhibitors[J].Crit Pathw Cardiol,2016,15(3):89-94.
[13] 简立国,刘士超,王鹏飞,等.血栓抽吸导管联合替罗非班对急性ST段抬高型心肌梗死恢复心肌"再灌注"的近期临床疗效观察[J].中国循环杂志,2014,29(7):501-504.
[14] 张大鹏,王乐丰,杜锦权,等.经血栓抽吸导管注射替罗非班和硝普钠对重度血栓负荷前壁急性心肌梗死患者急诊介入治疗效果的影响[J].中华心血管病杂志,2014,29(1):25-30.
[15] 张优,高传玉,李牧蔚,等.早期应用替罗非班在急性ST段抬高型心肌梗死择期经皮冠状动脉介入治疗患者中的疗效[J].中华内科杂志,2014,53(4):273-277.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 747541 位访问者


 ©《现代医学》编辑部
联系电话:025-83272481;83272479
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541