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八珍颗粒辅助化疗对晚期胃癌细胞免疫指标和P53蛋白、IL-6表达的影响
作者:钱晓兰  左云 
单位:张家港市第一人民医院 肿瘤科, 江苏 张家港 215600
关键词:八珍颗粒 胃癌 细胞免疫 P53蛋白 白细胞介素-6 
分类号:R735.2
出版年·卷·期(页码):2018·46·第十二期(1339-1344)
摘要:

目的:观察八珍颗粒辅助氟尿嘧啶+吡柔比星+奥沙利铂治疗晚期胃癌临床疗效及对细胞免疫指标和P53蛋白、白细胞介素-6(IL-6)表达的影响。方法:将80例晚期胃癌患者随机分为2组,对照组40例给予氟尿嘧啶+吡柔比星+奥沙利铂治疗,研究组40例在对照组基础上给予八珍颗粒辅助治疗,两组均以3周为1个疗程,持续治疗2个疗程。对比两组临床疗效,检测治疗前后细胞免疫指标和血清P53蛋白、IL-6表达水平,统计治疗期间不良反应发生情况。结果:研究组临床治疗总有效率为67.50%,显著高于对照组的40.00%(P<0.05);两组治疗后CD3+、CD4+、CD4+/CD8+和NK细胞水平均较治疗前显著升高(P<0.05),CD8+水平均较治疗前显著降低(P<0.05),且研究组CD3+、CD4+、CD8+、CD4+/CD8+和NK细胞水平均高于对照组(P<0.05);两组治疗后血清P53蛋白、IL-6表达水平均较治疗前显著降低(P<0.05),且研究组血清P53蛋白、IL-6表达水平均显著低于对照组(P<0.05)。研究组治疗期间不良反应发生率显著低于对照组(P<0.05)。结论:八珍颗粒辅助氟尿嘧啶+吡柔比星+奥沙利铂治疗晚期胃癌临床疗效显著,能明显改善细胞免疫指标,降低血清P53蛋白、IL-6表达水平。

Objective: To observe the clinical curative effect of Bazhen Granule assisted with Fluorouracil+Pirarubicin+Oxaliplatin in treatment of advanced gastric cancer and its influences on cellular immunity index and the expressions of P53 protein and interleukin-6 (IL-6). Methods: 80 patients with advanced gastric cancer were randomly divided into two groups, 40 cases in control group were given Fluorouracil+Pirarubicin+Oxaliplatin treatment, 40 cases in study group were given Bazhen Granule on the basis of the control group, the two groups were treated for 2 courses continuously, each course was 3 weeks. The clinical efficacy of the two groups after treatment was compared, the cellular immunity index and the expressions of P53 protein and interleukin-6 were detected in two groups before and after treatment, the incidence of adverse reactions during the treatment of the two groups was statistically analyzed. Results:The total effective rate of clinical treatment in the study group was 67.50%, which was significantly higher than 40.00% in the control group (P<0.05); after treatment, the levels of CD3+, CD4+, CD4+/CD8+ and NK cell in the two groups were significantly higher than those before treatment (P<0.05), and CD8+ levels were significantly lower than those before treatment (P<0.05), the levels of CD3+, CD4+, CD8+, CD4+/CD8+ and NK cell in the study group were better than those in the control group (P<0.05); after treatment, the levels of P53 protein and IL-6 in the two groups were significantly lower than those before treatment (P<0.05), the levels of serum P53 protein and IL-6 in the study group were significantly lower than those in the control group (P<0.05). The incidence rate of adverse reactions in the study group during the treatment was significantly lower than that in the control group (P<0.05). Conclusion:The clinical curative effect of Bazhen Granule assisted with Fluorouracil+Pirarubicin+Oxaliplatin in treatment of advanced gastric cancer is significant, it can significantly improve the cellular immunity index, reduce the expression level of P53 protein and IL-6.

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