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八珍颗粒辅助化疗对晚期胃癌细胞免疫指标和P53蛋白、IL-6表达的影响
作者:钱晓兰  左云 
单位:张家港市第一人民医院 肿瘤科, 江苏 张家港 215600
关键词:八珍颗粒 胃癌 细胞免疫 P53蛋白 白细胞介素-6 
分类号:R735.2
出版年·卷·期(页码):2018·46·第十二期(1339-1344)
摘要:

目的:观察八珍颗粒辅助氟尿嘧啶+吡柔比星+奥沙利铂治疗晚期胃癌临床疗效及对细胞免疫指标和P53蛋白、白细胞介素-6(IL-6)表达的影响。方法:将80例晚期胃癌患者随机分为2组,对照组40例给予氟尿嘧啶+吡柔比星+奥沙利铂治疗,研究组40例在对照组基础上给予八珍颗粒辅助治疗,两组均以3周为1个疗程,持续治疗2个疗程。对比两组临床疗效,检测治疗前后细胞免疫指标和血清P53蛋白、IL-6表达水平,统计治疗期间不良反应发生情况。结果:研究组临床治疗总有效率为67.50%,显著高于对照组的40.00%(P<0.05);两组治疗后CD3+、CD4+、CD4+/CD8+和NK细胞水平均较治疗前显著升高(P<0.05),CD8+水平均较治疗前显著降低(P<0.05),且研究组CD3+、CD4+、CD8+、CD4+/CD8+和NK细胞水平均高于对照组(P<0.05);两组治疗后血清P53蛋白、IL-6表达水平均较治疗前显著降低(P<0.05),且研究组血清P53蛋白、IL-6表达水平均显著低于对照组(P<0.05)。研究组治疗期间不良反应发生率显著低于对照组(P<0.05)。结论:八珍颗粒辅助氟尿嘧啶+吡柔比星+奥沙利铂治疗晚期胃癌临床疗效显著,能明显改善细胞免疫指标,降低血清P53蛋白、IL-6表达水平。

Objective: To observe the clinical curative effect of Bazhen Granule assisted with Fluorouracil+Pirarubicin+Oxaliplatin in treatment of advanced gastric cancer and its influences on cellular immunity index and the expressions of P53 protein and interleukin-6 (IL-6). Methods: 80 patients with advanced gastric cancer were randomly divided into two groups, 40 cases in control group were given Fluorouracil+Pirarubicin+Oxaliplatin treatment, 40 cases in study group were given Bazhen Granule on the basis of the control group, the two groups were treated for 2 courses continuously, each course was 3 weeks. The clinical efficacy of the two groups after treatment was compared, the cellular immunity index and the expressions of P53 protein and interleukin-6 were detected in two groups before and after treatment, the incidence of adverse reactions during the treatment of the two groups was statistically analyzed. Results:The total effective rate of clinical treatment in the study group was 67.50%, which was significantly higher than 40.00% in the control group (P<0.05); after treatment, the levels of CD3+, CD4+, CD4+/CD8+ and NK cell in the two groups were significantly higher than those before treatment (P<0.05), and CD8+ levels were significantly lower than those before treatment (P<0.05), the levels of CD3+, CD4+, CD8+, CD4+/CD8+ and NK cell in the study group were better than those in the control group (P<0.05); after treatment, the levels of P53 protein and IL-6 in the two groups were significantly lower than those before treatment (P<0.05), the levels of serum P53 protein and IL-6 in the study group were significantly lower than those in the control group (P<0.05). The incidence rate of adverse reactions in the study group during the treatment was significantly lower than that in the control group (P<0.05). Conclusion:The clinical curative effect of Bazhen Granule assisted with Fluorouracil+Pirarubicin+Oxaliplatin in treatment of advanced gastric cancer is significant, it can significantly improve the cellular immunity index, reduce the expression level of P53 protein and IL-6.

参考文献:

[1] 郭飞波,杨勇.果糖-1,6-二磷酸酶在胃癌组织中的表达及其对预后的预测价值[J].现代医学,2017,45(3):334-339.
[2] 施英瑛,王伟,冯睿,等.不同化疗方案在晚期胃癌患者中的疗效对比[J].癌症进展,2016,14(4):372-374.
[3] 李俊娇,葛信国.中药联合化疗治疗中晚期胃癌的研究进展[J].国际中医中药杂志,2017,39(7):662-665.
[4] 中华医学会.临床诊疗指南·肿瘤分册[M].北京:人民卫生出版社,2009:147-152.
[5] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:378-383.
[6] 黄珊,于天源,樊红.胃癌转移相关lncRNA的研究进展[J].东南大学学报(医学版),2017,36(5):856-860.
[7] GABBERT H E,MVLLER W,SCHNEIDERS A,et al.The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma[J].Cancer,2015,76(5):720-726.
[8] 阎吕军.免疫细胞治疗联合化疗对晚期胃癌患者的疗效及对血清IL-6表达水平的影响[J].山西医科大学学报,2014,45(11):1074-1077.
[9] GARRIDO M,FONSECA P J,VIEITEZ J M,et al.Challenges in first line chemotherapy and targeted therapy in advanced gastric cancer[J].Expert Rev Anticancer Ther,2014,14(8):887-900.
[10] NAKAMURA A,NAKAJIMA G,OKUYAMA R,et al.Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase[J].Gastric Cancer,2014,17(1):188-195.
[11] 李雄.卡培他滨、奥沙利铂联合吡柔比星治疗进展期老年胃癌67例[J].中国药业,2015,24(17):129-130.
[12] VAN C E,BONI C,TABERNERO J,et al.Docetaxel plus oxaliplatin with or without fluorouracil or capecitabine in metastatic or locally recurrent gastric cancer:a randomized phase Ⅱ study[J].Ann Oncol,2015,26(1):149-156.
[13] 俞森权,陈冬,庞德湘.庞德湘教授气血津液辨证之胃癌化疗应用初探[J].浙江中医药大学学报,2016,40(11):829-831.
[14] 宋卓,苏春雨,徐竞男,等.扶正解毒法防治胃癌的理论基础及循证依据[J].中医杂志,2016,57(10):829-833.
[15] 熊霸,张眉岸,黄锡英,等.老年晚期胃癌气血两虚证患者行鳖甲化坚汤联合替吉奥治疗的临床疗效[J].中国医学创新,2016,13(26):44-47.
[16] 魏开建,杜建.八珍颗粒对中晚期气血两虚型恶性肿瘤患者免疫功能的影响[J].中医药导报,2010,16(12):25-28.
[17] 郭经锋,吴锋,邢辉,等.八珍颗粒联合紫杉醇、卡铂方案治疗老年晚期非小细胞肺癌的疗效观察[J].临床和实验医学杂志,2015,14(6):449-452.
[18] 陈德庆.中医药联合化疗治疗胃癌术后40例临床观察[J].中医临床研究,2016,8(21):124-125.

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