Objective:To investigate the occupational stress level among ICU nurses and analyze its correlation with health quotient. Methods:A total of 276 nurses from ICU units in 3 tertiary hospitals in our city were randomly selected as subjects. General information was collected and the ICU nurses' work stress scale and health quotient questionnaire were used to determine occupational stress levels and health quotient. The effects of occupational stress in ICU nurses and its correlation with health quotient was analyzed. Results:(1) 255 valid questionnaires were returned from 276 questionnaires, and the effective recovery rate was 92.39%; (2) The total score of occupational stress was (96.87±15.78), and the average conversion score of 7 stress source blocks was between 2.11 and 3.23. The top three scores were patient care, promotion and bonus, work environment; (3) Working years(P=0.033), working hours per week(P=0.035) and night shift frequency per week (P=0.023)were the independent influencing factors of occupational stress of ICU nurses; (4) The total score of health quotient was (23.47±6.89). The actual score was (7.18±2.04), and the occupational stress was negatively correlated with the health quotient (r=-0.472, P=0.031).Conclusion:Although ICU nurses have a good score of health quotients, considering their unique occupational characteristics, we should actively relieve their occupational stress and improve their health quotient.