Objective:To analysis of the risk factors of renal failure in patients with gout.Methods:126 patients undergoing gout in our rheumatology department from May 2014 to May 2017 were retrospectively analyzed. patients were were divided into renal failure and renal insufficiency group. Their demographic data, clinical manifestations, drugs of treatment, complications and laboratory dates were analyzed. Data were statisticallyanalyzed by SPSS 19.0.Results:The incidence of renal failure was 41.27%. Compared with the normal renal function group, the number of patients with NSAIDs in the renal insufficiency group was significantly higher than that in normal renal function group (P<0.05), and the levels of CRP and serum creatinine were significantly increased (P<0.05), while the level of serum creatinine was significantly decreased in patients with renal insufficiency (P<0.05). The proportion of male, old age, ischemic cardio-cerebrovascular disease and hypertension in renal insufficiency group were significantly higher than those in the normal renal function group (P<0.05). There were positive correlations between renal failure in patients with gout and ischemic cerebrovascular disease, hypertension, age of onset, joint symptoms, serum creatinine level, NSAIDs treatment, CRP were significant (P<0.05); There were negative correlations between renal failure in patients with gout and urinary PH, hemoglobin level were significant (P<0.05); NSAIDs, age of onset and pH of urine were high risk factors for renal failure in gout patients (OR:5.987,0.839,0.286,1.086,P<0.05). Conclusion:The age of onset was a high risk factor for the disease. Therefore, it was necessary to pay attention to the elderly at aearly stage. We should treat uric acid timely to reduce the level of blood uric acid in order to prevent and slow down the occurrence of renal failure complications. |
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