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rtA181V和rtA181T两种耐药模式的CHB患者血清HBsAg水平比较
作者:庞亚博  刘影  彭华彬  李莎  汪莉萍  韩方正 
单位:徐州医科大学附属医院 感染科, 江苏 徐州 221000
关键词:慢性乙型肝炎 HBV耐药变异 HBsAg 
分类号:R575.1
出版年·卷·期(页码):2018·46·第八期(853-857)
摘要:

目的:比较rtA181V和rtA181T两种耐药模式的慢性乙型肝炎(CHB)患者血清HBsAg的水平。方法:回顾性分析徐州医科大学附属医院2015年9月至2017年10月之间就诊于感染科门诊及住院部,口服阿德福韦酯(ADV)单药治疗后发生rtA181V和rtA181T耐药变异的CHB患者共217例,其中rtA181V耐药模式111例,rtA181T耐药模式106例,比较两组患者血清HBsAg的含量。结果:rtA181T组血清HBsAg水平显著低于rtA181V组(P<0.05)。结论:发生rtA181T耐药变异模式的CHB患者,血清HBsAg含量低于耐药模式为rtA181V的患者。

Objective:To compareserum HBsAg level in CHB patients with rtA181T and rtA181V drug-resistant mutation. Methods:217ADV treated patients were enrolled in our hospital from 2015 to 2017,including 111 rtA181V mutationpatients and 106 rtA181T mutation patients.Serum HBsAg of these two mutation groups was compared by retrospective comparison and analysis. Results:Serum HBsAg level of rtA181T mutation was significantly lower than that in rtA181V group (P<0.05). Conclusion:CHB patients with rtA181T mutation have a lower expression of HBsAgthan rtA181V mutation patients.

参考文献:

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