目的：探讨专用扩皮针在超声引导结合微插鞘管行经外周静脉置入中心静脉导管（PICC）术中的应用。方法：选择我院收治的恶性肿瘤行PICC术患者84例，按照随机数字表法分为观察组和对照组各42例，两组患者均行超声引导结合微插鞘管的PICC术，其中对照组采用常规扩皮刀扩皮，观察组采用专用扩皮针，比较两组患者推送血管鞘成功率、置管后渗血情况、置管疼痛程度以及置管1周内平均换药次数。结果：观察组患者推送血管鞘成功率显著高于对照组（P<0.05），置管后24、72 h穿刺点渗血均明显少于对照组（P<0.05），置管疼痛程度明显轻于对照组（P<0.05），置管后1周内平均换药次数明显少于对照组（P<0.05）。结论：PICC置管专用扩皮针在行超声引导结合微插鞘管的PICC术中可有效提高推送血管鞘一次成功率，减少置管后渗血及换药次数，减轻患者置管疼痛感，值得临床推广。

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