Objective:To explore the therapeutic effect of simvastatin combined with Tripterygium on patients with diabetic nephropathy. Methods:Ninety-eight patients with diabetic nephropathy treated in our hospital were divided into simvastatin group (n=49) and combination group (n=49) by random number table method. The simvastatin group received simvastatin while the combination group was treated with Tripterygium glycosides in addition to simvastatin. After 3-month treatment, the total effective rate, 24 h urinary total protein (24 h UTP), hypersensitive C-reactive protein (hs-CRP), renal function, blood lipid and adverse reactions were observed. Results:After treatment for 3 months, the total effective rate (91.9%) in the combination group was much higher than that 75.5% of the simvastatin group (P<0.05). The levels of 24 h UTP and hs-CRP in the two groups were much lower than those before the treatment (P<0.05), while the levels in combination group were much lower than those in simvastatin group after treatment for 1 month, 2 months and 3 months (P<0.05). The levels of SCr, BUN, TC, TG and LDL-C in the two groups were significantly decreased compared with those before the treatment (P<0.05). Compared with simvastatin group, the levels in combination group were decreased more significantly. And there was no statistically significant difference in adverse reactions between the two groups (P>0.05). Conclusion:The treatment of simvastatin combined with Tripterygium glycosides is effective for patients with diabetic nephropathy, which can improve the renal function and reduce the levels of serum lipid and hs-CRP. It is safe, reliable and worthy of clinical application.