海洋是药物开发的重要资源，从中获得的化合物大多具有良好的生物活性，尤其是抗肿瘤活性。海洋天然产物的抗肿瘤活性作用主要包括抑制癌细胞增殖、迁移和诱导癌细胞凋亡两个方面，其中诱导成癌细胞凋亡是其能否有效发挥抗癌作用的关键。海洋天然产物介导肝癌细胞凋亡的机制主要包括调节蛋白酶和线粒体跨膜电位的水平、抗凋亡蛋白与促凋亡蛋白的比例、细胞周期调控等几个方面。作者对海洋生物及其代谢产物诱导肝癌细胞凋亡的研究进展作一综述，为今后海洋天然产物活性的筛选以及抗肿瘤靶点的研究提供依据。

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