和肽素水平对重症肺炎严重程度的评价作用-现代医学

和肽素水平对重症肺炎严重程度的评价作用

单位：1. 盱眙县人民医院重症医学科, 江苏盱眙 211700;
2. 徐州医科大学附属医院急救中心, 江苏徐州 221000

分类号：R446.11

出版年·卷·期（页码）：2018·46·第七期（745-747）

摘要：

目的：研究和肽素水平在重症肺炎严重程度评价中的作用。方法：对已确诊重症肺炎的32例患者在纳入研究后96 h内，每24 h检测和肽素水平，并计算96 h内和肽素水平的下降率，同时96 h内每日作急性生理与慢性健康（APACHE Ⅱ）评分，根据28 d后生存情况将患者分为生存组和死亡组，比较两组患者第1、4天平均和肽素水平及96 h内和肽素水平下降率的差异，观察两组患者96 h内和肽素水平的变化与APACHE Ⅱ评分变化的相关性。结果：生存组和死亡组第1、4天平均和肽素水平及96 h内和肽素水平下降率差异有统计学意义，两组96 h内和肽素水平的变化与APACHE Ⅱ评分变化呈显著正相关。结论：动态监测和肽素水平对重症肺炎严重程度的评估有一定作用。

Objective: To study the evaluation effect of copeptin levels on the severity of severe pneumonia. Methods: A total of 32 patientswith severe pneumonia were enrolled in this study.The level of copeptin was measured every 24 hours during 96 hours after inclusion in this study and the decreasing rate of copeptin level within 96 hours was calculated. At the same time, daily acute physical and chronic health score (APACHE Ⅱ) was calculated within 96 hours. The patients were divided into survival group and death group based on survival after 28 days. The difference of copeptin average level on the 1st day and the 4th day in the two groups were compared, and the decreasing rate of copeptin level in the 96 hours of the two groups was compared too. The correlation between changes of copeptin levels and changes in APACHE Ⅱ scores within 96 hours was observed in both groups. Results: There was a statistically significant difference in copeptin average level on the 1st and 4th days between the survival group and the death group. There was a statistically significant difference in the copeptin level decreasing rate within 96 hours between the two groups also. The changes of copeptin levels within 96 hours were significantly positively correlated with the changes of APACHE Ⅱ scores. Conclution: The dynamic monitoring of copeptin levels has a role in the evaluation of the severity of severe pneumonia.

参考文献：

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