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小凹蛋白-1、E-cad和P53在甲状腺乳头状癌中的表达及临床意义
作者:张杰东1  方媛2  刘兰侠1  刘杜先1 
单位:1. 南京市第二医院 病理科, 江苏 南京 210003;
2. 南京市第一医院 病理科, 江苏 南京 210000
关键词:甲状腺乳头状癌 小凹蛋白-1 小凹蛋白 P53 免疫组化 
分类号:R736.1
出版年·卷·期(页码):2018·37·第七期(741-744)
摘要:

目的:探讨小凹蛋白-1、上皮型钙黏蛋白(E-cad)和P53在甲状腺乳头状癌中的表达及其与临床病理特征之间的关系。方法:应用免疫组化法检测96例甲状腺乳头状癌组织和34例正常甲状腺组织中小凹蛋白-1、E-cad和P53蛋白的表达,分析其与临床病理特征的关系。结果:小凹蛋白-1、P53在甲状腺乳头状癌中的阳性表达率(分别为72.92%、68.75%)明显高于正常甲状腺组织(分别为23.53%、14.71%),差异有统计学意义(P<0.01)。E-cad在甲状腺乳头状癌中的阳性表达率为22.92%,低于正常甲状腺组织的阳性表达率(100%),差异有统计学意义(P<0.01)。小凹蛋白-1、E-cad和P53蛋白在甲状腺乳头状癌中的表达与颈部淋巴结转移相关(均P<0.05),而与性别、年龄、肿瘤大小、TNM分期无明显相关性(均P>0.05)。结论:小凹蛋白-1和P53在甲状腺乳头状癌中具有高表达的特性,而E-cad在甲状腺乳头状癌中低表达。三者在甲状腺乳头状癌的发生、发展及转移中起重要作用,为甲状腺乳头状癌的临床诊断和预后提供重要理论依据。

Objective: To investigate the expression of Caveolin-1,E-cad and P53 in papillary thyroid carcinoma and analyze the relationship with clinicopathological parameters.Methods:The expression of Caveolin-1, E-cad and P53 in 96 cases of papillary thyroid carcinoma and 34 cases of normal thyroid tissue were detected by immunohistochemistry. The relationship with the clinicopathological parameters was also explored.Results:The positive expression rates of Caveolin-1 and P53 in papillary thyroid carcinoma (72.92%,68.75%,respectively) were both significantly higher than those in normal thyroid tissue(23.53%,14.71%,respectively). There was statistically significant difference (P<0.01). The positive expression rate of E-cad in papillary thyroid carcinoma was 22.92%,which was significantly lower than that in normal thyroid tissues(P<0.01). The expression of Caveolin-1, E-cad and P53 were all correlated with the lymph node metastasis in papillary thyroid carcinoma (P<0.05), however, they were found not correlated with sex, age, tumor size and TNM stage of papillary thyroid carcinoma (P>0.05). Conclusion: Caveolin-1 and P53 are highly expressed in papillary thyroid carcinoma, whereas E-cad is low expressed in papillary thyroid carcinoma. They may play an important role in the occurrence, progression and metastasis of papillary thyroid carcinoma,and provide theoretically basis for the clinical diagnosis and prognosis of papillary thyroid carcinoma.

参考文献:

[1] LIU Z,KAKUDO K,BAI Y,et al.Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma,a novel predictor for lymph node metastasis; possible morphological indicator of epithelial mesenchymal transition[J].J Clin Pathol,2011,64(4):325-329.
[2] LEE Y M,LEE J B.Prognostic value of epidermal growth factor receptor,p53 and galectin-3 expression in papillary thyroid carcinoma[J].J Int Med Res,2013,41(3):825-834.
[3] ABROSIMOV A Y.The new international histological classification of thyroid tumors[J].Arkh Patol,2018,80(1):37-45.
[4] 陈杰.注意甲状腺肿瘤病理诊断中的问题[J].中华病理学杂志,2014,43(5):289-290.
[5] KODAMA R,KATO M,FURUTA S,et al.ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence[J].Genes Cells,2013,18(1):32-41.
[6] DIAZ J,MENDOZA P,ORTIZ R,et al.Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation,migration and invasion[J].J Cell Sci,2014,127(Pt11):2401-2406.
[7] SHANKAR J,WISEMAN S M,MENG F,et al.Coordinated expression of galectin-3 and caveolin-1 in thyroid cancer[J].J Pathol,2012,228(1):56-66.
[8] CEYRAN A B,SENOL S,SIMSEK B C,et al.Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid:the prognostic importance of E-cadherin[J].Int J Clin Exp Pathol,2015,8(4):3670-3680.
[9] 樊玉文,张园,赵卫平,等.β-半乳糖凝集素-3与上皮钙黏蛋白在甲状腺乳头状癌组织中的表达及其意义[J].东南大学学报(医学版),2011,30(4):598-602.
[10] LACO J,RYSKA A,CAP J,et al.Expression of galectin-3,cytokeratin19,neural cell adhesion molecule and E-cadherin in certain variants of papillary thyroid carcinoma[J].Cesk Patol,2008,44(4):103-107.
[11] BAI J A,XU G F,YAN L J,et al.SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis[J].World J Gastroenterol,2015,21(20):6180-6193.
[12] 张伟华,闫斌,刘可心.CK19、P53在甲状腺癌中的表达及其临床意义[J].中国实用医药,2017,12(1):79-80.
[13] 祁燕云,赵志强,王泽民.血管内皮生长因子与P53蛋白及Ki-67蛋白在甲状腺乳头状癌组织中的表达及临床意义[J].中国医药,2013,8(4):521-522.

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