小凹蛋白-1、E-cad和P53在甲状腺乳头状癌中的表达及临床意义-现代医学

小凹蛋白-1、E-cad和P53在甲状腺乳头状癌中的表达及临床意义

单位：1. 南京市第二医院病理科, 江苏南京 210003;
2. 南京市第一医院病理科, 江苏南京 210000

分类号：R736.1

出版年·卷·期（页码）：2018·37·第七期（741-744）

摘要：

目的：探讨小凹蛋白-1、上皮型钙黏蛋白（E-cad）和P53在甲状腺乳头状癌中的表达及其与临床病理特征之间的关系。方法：应用免疫组化法检测96例甲状腺乳头状癌组织和34例正常甲状腺组织中小凹蛋白-1、E-cad和P53蛋白的表达，分析其与临床病理特征的关系。结果：小凹蛋白-1、P53在甲状腺乳头状癌中的阳性表达率（分别为72.92%、68.75%）明显高于正常甲状腺组织（分别为23.53%、14.71%），差异有统计学意义（P<0.01）。E-cad在甲状腺乳头状癌中的阳性表达率为22.92%，低于正常甲状腺组织的阳性表达率（100%），差异有统计学意义（P<0.01）。小凹蛋白-1、E-cad和P53蛋白在甲状腺乳头状癌中的表达与颈部淋巴结转移相关（均P<0.05），而与性别、年龄、肿瘤大小、TNM分期无明显相关性（均P>0.05）。结论：小凹蛋白-1和P53在甲状腺乳头状癌中具有高表达的特性，而E-cad在甲状腺乳头状癌中低表达。三者在甲状腺乳头状癌的发生、发展及转移中起重要作用，为甲状腺乳头状癌的临床诊断和预后提供重要理论依据。

Objective: To investigate the expression of Caveolin-1,E-cad and P53 in papillary thyroid carcinoma and analyze the relationship with clinicopathological parameters.Methods:The expression of Caveolin-1, E-cad and P53 in 96 cases of papillary thyroid carcinoma and 34 cases of normal thyroid tissue were detected by immunohistochemistry. The relationship with the clinicopathological parameters was also explored.Results:The positive expression rates of Caveolin-1 and P53 in papillary thyroid carcinoma (72.92%,68.75%,respectively) were both significantly higher than those in normal thyroid tissue(23.53%,14.71%,respectively). There was statistically significant difference (P<0.01). The positive expression rate of E-cad in papillary thyroid carcinoma was 22.92%,which was significantly lower than that in normal thyroid tissues(P<0.01). The expression of Caveolin-1, E-cad and P53 were all correlated with the lymph node metastasis in papillary thyroid carcinoma (P<0.05), however, they were found not correlated with sex, age, tumor size and TNM stage of papillary thyroid carcinoma (P>0.05). Conclusion: Caveolin-1 and P53 are highly expressed in papillary thyroid carcinoma, whereas E-cad is low expressed in papillary thyroid carcinoma. They may play an important role in the occurrence, progression and metastasis of papillary thyroid carcinoma,and provide theoretically basis for the clinical diagnosis and prognosis of papillary thyroid carcinoma.

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