两种不同的促排卵方案在辅助生殖技术孕育结局中的疗效分析-现代医学

两种不同的促排卵方案在辅助生殖技术孕育结局中的疗效分析

单位：新疆维吾尔自治区妇幼保健院辅助生殖科, 新疆乌鲁木齐 830000

分类号：R321-33

出版年·卷·期（页码）：2018·46·第六期（700-703）

摘要：

目的：探讨卵泡期长方案和黄体中期短针长方案两种促排卵方案在辅助生殖技术孕育结局中的疗效。方法：回顾性分析行辅助生殖技术治疗的523例患者，按照促排卵方式分为卵泡期长方案组（372例）和黄体中期短针长方案组（151例），分析两种促排卵方案对于辅助生殖技术孕育结局的影响因素及疗效。结果：卵泡期长方案组的优胚率明显高于黄体中期短针长方案组，且雌二醇浓度低于黄体期长方案组，差异具有统计学意义（P<0.05）。卵泡期长方案组的临床妊娠率明显高于黄体中期短针长方案组，差异具有统计学意义（P<0.05）。卵泡期长方案组的生化妊娠率明显低于黄体中期短针长方案组，差异具有统计学意义（P<0.05）。双胎妊娠率、流产率及卵巢过度刺激综合征（ovarian hyperstimulation syndrome，OHSS）发生率差异无统计学意义（P>0.05）。结论：卵泡期长方案在辅助生殖技术孕育结局中可显著提高优胚率、妊娠率，同时降低生化妊娠率、雌二醇浓度，在辅助生殖技术孕育结局中的疗效明显优于黄体中期短针长方案。

Objective:To investigate the efficacy of ovulation promotion in in vitro fertilization(IVF)with long follicular stage regimen and the mid luteal long protocol needle.Methods:A retrospective analysis of 523 patients with IVF treated with assisted reproductive technology was made. According to the mode of ovulation promotion, they weredivided into two groups:the long follicular stage group (372 cases) and the middle luteal short needle length regimen group (151 cases). The factors influencing the outcome of IVF and the therapeutic effect were analyzed. Results:The optimal embryo rate in the long follicular stage group was significantly higher than that in the middle luteal short needle length regimen group,and the concentration of estradiol was lower than the middle luteal short needle length regimen group,the difference was statistically significant(P<0.05).The clinical pregnancy rate in the long follicular stage group was significantly higher than that in the middle luteal short needle length regimen group,the difference was statistically significant(P<0.05).The biochemical pregnancy rate in the long follicular stage group was significantly lower than that in the middle luteal short needle length regimen group,and the difference was statistically significant(P<0.05).There was no significant difference in abortion rate and ovarian hyperstimulation syndrome(OHSS) incidence(P>0.05).Conclusion:The long follicle stage regimen can significantly increase optimal embryo rate and pregnancy rate, and reduce biochemical pregnancy rate and estradiol concentration.The pregnant outcomeis obviously superior to the mid luteal long protocol in IVF needle.

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