Objective:To analyze the efficacy and influential factors of tacrolimus combined with glucocorticoids in the treatment of primary nephrotic syndrome. Methods:62 cases of primary nephrotic syndrome treated with tacrolimus combined with glucocorticoids were collected. The efficacy, the related influencial factors and the adverse events were evaluated. Results:21 cases(33.9%) were partially remitted and 20 cases(32.2%) were completely remitted. The level of aspartate transaminase(AST) (OR 1.193, 95% CI 1.041-1.368, P=0.011) before medication was the related factor of remission. Tacrolimus concentration(OR 1.492, 95% CI 1.025-2.173,P=0.037), and whether hematuria or not (OR 0.173, 95% CI 0.04-0.737,P=0.018) before medication were related factors for complete remission. All the patients with IgM nephropathy were relieved after treatment. In the treatment process, the incidence rate of the liver function injury,renal function injury, diabetes and infection were 19%,16%,16% and 18%. Conclusion:There is a high clinical remission rate after the treatment of tacrolimus combined with glucocorticoids in primary nephrotic syndrome. The main side effects of tacrolimus combined with glucocorticoids are the liver function injury,renal function injury, diabetes and infection. |
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