血清分泌型卷曲相关蛋白5与中老年2型糖尿病代谢综合征的相关性研究-现代医学

血清分泌型卷曲相关蛋白5与中老年2型糖尿病代谢综合征的相关性研究

单位：1. 贵州医科大学附属医院内分泌科, 贵州贵阳 550004;
2. 黔南民族医学高等专科学校, 贵州都匀 558000;
3. 贵阳市第一人民医院内分泌科, 贵州贵阳 550003

分类号：R589.1

出版年·卷·期（页码）：2018·46·第六期（629-632）

摘要：

目的：探讨血清分泌型卷曲相关蛋白5（SFRP-5）与中老年2型糖尿病（T2DM）代谢综合征（MS）的相关性。方法：选取健康体检的人群和住院治疗的T2DM患者作为研究对象，分为体检健康组（正常对照组）、单纯糖尿病组（非MS组）、糖尿病合并代谢综合征组（MS组），每组各30例，年龄≥ 45岁，观察年龄、体重指数（BMI）、腰围、臀围、腰臀比、糖化血红蛋白（HbA1c）、空腹血浆胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、高敏C反应蛋白（hsCRP）、白细胞介素-1（IL-1）、血清SFRP-5等指标。结果：正常对照组、非MS组和MS组BMI、腰围、臀围、腰臀比、HbA1c、FINS、HOMA-IR、hsCRP、IL-1、血清SFRP-5等指标比较差异具有统计学意义（P<0.05）；相关分析提示，血清SFRP-5水平与BMI、腰臀比、HbA1c、FINS、HOMA-IR、hsCRP、IL-1呈负相关（r=-0.622、-0.466、-0.461、-0.527、-0.588、-0.313、-0.538，均P<0.05）；多元线性逐步回归分析显示，BMI、HOMA-IR、FINS和IL-1是SFRP-5的独立影响因素。结论：血清SFRP-5与中老年T2DM合并MS患者的BMI、HOMA-IR、FINS和IL-1密切关联。

Objective:To explore the relationship between serum secreted frizzled-related protein-5 (SFRP-5)and elderly people type 2 diabetes mellitus (T2DM)metabolic syndrome(MS). Methods:Population for health examination and T2DM patients hospitalization from our hospital were selected as research subjects, they were divided into physical examination healthy person (control group), simple diabetes group (non MS group), diabetes complicated with MS group (MS group),30 cases in each group,45 years of age or older. Age, waist circumference,hipline circumference,the ratio of waist circumference to hip circumference,glycated hemoglobin(HbA1c),fasting insulin(FINS),insulin resistance(HOMA-IR),hypersensitivity C reactive protein(hsCRP),interleukin-1(IL-1),serum SFRP-5 content were measured.Results:The index of waist circumference, hipline circumference, the ratio of waist circumference to hip circumference,HbA1c,FINS,HOMA-IR,hsCRP,IL-1,serum SFRP-5 had statistical significance among three groups (P<0.05). Correlation analysis showed, serum SFRP-5 level was negatively correlated with BMI, the ratio of waist circumference to hip circumference,HbA1c,FINS,HOMA-IR,hsCRP,IL-1(r=-0.622、-0.466、-0.461、-0.527、-0.588、-0.313、-0.538,P<0.05). Multiple linear stepwise regression analysis showed that HOMA-IR,FINS and IL-1 were independent influencing factors of SFRP-5. Conclusion:Serum SFRP-5 is closely associated with BMI,HOMA-IR, FINS, and IL-1 in T2DM patients combined with MS.

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