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环状RNA在骨相关疾病中的研究进展
作者:何萧  康思淼  李博源  潘海乐 
单位:哈尔滨医科大学附属第二医院 骨外科, 黑龙江 哈尔滨 150086
关键词:环状RNA 非编码RNA 骨相关疾病 生物标志物 药物靶点 综述 
分类号:R681
出版年·卷·期(页码):2018·46·第五期(594-597)
摘要:

环状RNA (circular RNAs,circRNA)以特殊的共价闭合环结构以及在多种疾病发生发展中的异常表达逐渐成为非编码RNA (non-coding RNAs,ncRNA)研究的新热点。该类转录本具有吸附微小RNA (microRNA,miRNA)、调控相关基因转录、参与重要蛋白生成等诸多功能。随着对circRNA研究的加深,发现其与多种骨相关疾病的发生、转归等过程存在显著相关性。骨相关疾病以其高发病率和致残率一直威胁着人类健康,随着对该类疾病基因层面认知的深入,关于其分子机制和药物靶点的研究逐步被学术界所认可,并在一定程度上加以阐明。本文作者就circRNA与骨相关疾病的研究进展作一综述。

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