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ARDS合并间质性肺病患者应用俯卧位通气的临床价值分析
作者:王茂泽  石慧芳  陈亚红  王应琼  王秋婷  陈兴峰 
单位:海南医学院第二附属医院 呼吸内科, 海南 海口 570311
关键词:急性呼吸窘迫综合征 间质性肺病 俯卧位通气 
分类号:R563.8
出版年·卷·期(页码):2018·46·第五期(502-506)
摘要:

目的:探讨俯卧位通气方式对急性呼吸窘迫综合征(ARDs)合并间质性肺病(ILD)患者的临床价值。方法:收集本院2014年8月至2016年8月收治的74例ARDS患者的临床资料,根据是否合并ILD分为观察组(合并ILD,31例)和对照组(不合并ILD,43例)。比较两组在俯卧位通气治疗前后及组间疗效差异,即呼吸动力学指标变化、氧和指数及3个月生存曲线组间差异。结果:两组治疗前基础情况差异无统计学意义(P>0.05)。两组治疗后氧和指数均明显改善(P<0.05)。观察组行俯卧位通气后,其呼气末正压显著升高(9.54±0.85 vs 10.63±0.86,P<0.05);对照组呼吸频率明显下降(23.17±3.91 vs 21.89±2.53,P<0.05)。治疗后观察组较对照组动态呼吸顺应性好(18.78±3.92 vs 17.83±3.87,P<0.05)。根据K-M曲线分析比较,观察组3个月生存率明显较对照组低(χ2=10.342,P<0.05)。结论:俯卧位通气对ARDS合并ILD患者在短期疗效上效果明显,可以提高肺的顺应性。

Objective: To analyze the clinical value of prone position ventilation(PPV) for acute respiratory distress syndrome(ARDS) and interstitial lung disease(ILD) patients.Methods: Seventy-four patients with ARDS collected in our hospital from August 2014 to August 2016 were divided into observation group 31 cases(patients with ILD) and control group 43 cases (patients without ILD). The difference was compared between the two groups before and after treatment, such as the difference of respiratory dynamics indexes and oxygen index and the 3 month K-M survival curves.Results: There was no significant difference between the two groups before treatment (P>0.05). The changes of the relevant indicators in each group before and after treatmentm were compared, the oxygen index were significantly improved (P<0.05).After the treatment of PPV, the observation group of PEEP increased significantly (9.54±0.85 vs 10.63±0.86,P<0.05);The control group underwent PPV, the respiratory frequency decreased significantly(23.17±3.91 vs 21.89±2.53,P<0.05). After treatment, the observation group was better than the control group in Dynamic respiratory compliance(18.78±3.92 vs 17.83±3.87, P<0.05).According to the K-M curve, the observation group had significant lower survival rate than the control group in the 3 month, the difference was statistically significant (χ2=10.342,P<0.05).Conclusion: PPV for ARDS patients with ILD has obvious short-term effect, it can ameliorate the patients' compliance significantly.

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