放疗联合5-氟尿嘧啶局部化疗对头面部及四肢皮肤癌的临床疗效观察-现代医学

放疗联合5-氟尿嘧啶局部化疗对头面部及四肢皮肤癌的临床疗效观察

单位：钟祥市人民医院肿瘤科, 湖北钟祥 431900

分类号：R739.5;R730.5

出版年·卷·期（页码）：2018·46·第五期（483-486）

摘要：

目的：探讨放疗联合5-氟尿嘧啶（5-FU）局部化疗对头面部及四肢皮肤癌的临床疗效。方法：选取2015年10月至2017年10月于本院诊疗的50例头面部及四肢皮肤癌患者，采用随机信封法将患者分为对照组（25例）和观察组（25例），对照组给予单纯放疗治疗，观察组给予5-FU局部化疗联合放疗治疗方案。对两组患者治疗后病理、临床疗效、毒副作用以及复发情况进行比较。结果：观察组患者治疗后最大肿瘤直径缩小明显，临床治疗总有效率为56%，较对照组的36%显著升高（P<0.05）；两组患者治疗过程中不良反应之间差异无统计学意义（P>0.05）；观察组患者治疗后6~12个月局部复发率明显低于对照组（P<0.05），无复发及转移的比例高于对照组（P<0.05）。结论：放疗联合5-FU局部化疗对头面部及四肢皮肤癌患者的临床疗效显著，治疗方案安全可行，值得推广。

Objective: To investigate the effect of radiotherapy combined with 5-fluorouracil local chemotherapyin the treatment of skin cancer on face, head and limbs.Methods: A total of 50 patients who were diagnosed as skin cancer in our hospital from October 2015 to October 2017 were allocated randomly into two groups. The control group was given radiotherapy while the observation group was given 5-FU local chemotherapy combined with radiotherapy. The pathology, clinical curative effect, adverse reaction and local recurrence of the two groups were compared after the treatment.Results: The treatment of observation group can significantly reduce diameter of the largest tumor(P<0.05) and do not increase adverse reactions when compared with the control group(P>0.05). The effective rate was 56% in the observation group and 36% in the control group(P<0.05). The proportion of local recurrence or non-recurrence and non-metastasis of the observation group was significantly different from the control group(P<0.05) after treatment 6 to 12 months.Conclusion: Radiotherapy combined with 5-FU local chemotherapy turns out to be an ideal therapeutic regimen, which is safe and worth to be popularized.

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