T3、T4、TSH和HGB的联合检测在儿童甲状腺功能减退症临床诊断中的意义-现代医学

T3、T4、TSH和HGB的联合检测在儿童甲状腺功能减退症临床诊断中的意义

单位：青海省妇女儿童医院儿保科, 青海西宁 810007

分类号：R725;R581.2;R446

出版年·卷·期（页码）：2018·46·第三期（302-305）

摘要：

目的：探讨三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（thyrotropin，thyroid stimulating hormone，TSH）和血红蛋白（hemoglobin，HGB）联合检测在儿童甲状腺功能减退症（甲减）临床诊断中的作用和意义。方法：选取2015年5月至2017年5月本院门诊收治的60例儿童甲减患者为观察组，选取同期健康体检儿童30例为对照组。收集患者血清，检测血清中T3、T4、TSH和HGB水平变化并进行统计分析。结果：与对照组相比，观察组患者血清内FT3、FT4、T3和T4浓度有明显降低，血清内TSH浓度有明显上升，HGB浓度明显下降，差异具有统计学意义（P<0.05）。T4、TSH和HGB各项指标在观察组患者的单项检测阳性率明显低于各指标联合检测的阳性率，差异具有统计学意义（P<0.05）。结论：儿童甲减患者血清中T3、T4、TSH和HGB含量呈异常表达状态；T3、T4、TSH和HGB的联合检测在儿童甲减的诊断中具有重要的临床意义。

Objective: To investigate the clinical value of combined detection of triiodothyronine (T3), thyroid hormone (T4), thyroid stimulating hormone(TSH) and hemoglobin (HGB).Methods: From May 2015 to May 2017, 60 cases of hypothyroidism in our hospital were selected as the observation group,30 healthy children in the same period were selected as the control group. The patient sera were collected and serum levels of T3, T4, TSH and HGB were measured for statistical analysis. Results: Compared with the control group, the concentration of FT3, FT4, T3 and T4 in the serum of patients in the observation group were significantly decreased, the concentration of TSH in serum was increased and the concentration of HGB was decreased significantly (P<0.05). The individual test positive rate of T4, TSH and HGBin the observation group was significantly lower than that of the combined detection of each index, the difference was statistically significant (P<0.05).Conclusion: The levels of T3, T4, TSH and HGB in children with hypothyroidism are abnormally expressed.The combined detection of T3, T4, TSH and HGB has important clinical significancein the diagnosis of hypothyroidism in children.

参考文献：

[1] 支朦朦,袁勇贵,李玲.甲状腺功能与情绪及认知障碍关联的研究进展[J].东南大学学报:医学版,2016,35(4):612-616.
[2] 齐颖.亚临床甲状腺功能减退症孕妇左旋甲状腺素治疗剂量及影响因素探讨[J].标记免疫分析与临床,2016,23(5):484-486.
[3] 董懿,董红梅.甲状腺机能减退和亚临床甲状腺机能减退时缺血修饰蛋白的变化[J].标记免疫分析与临床,2016,23(5):539-542.
[4] 代琳,安红歌.亚临床甲状腺功能减退症对孕妇母婴结局的影响[J].检验医学与临床,2017,14(12):1793-1795.
[5] 王秋伟,王淮燕,蒋健,等.常州地区新生儿先天性甲状腺功能减退症十年筛查结果分析[J].中国全科医学,2012,36(15):4247-4249.
[6] 徐爱晶,李堂.儿童甲状腺功能减低并发垂体增生8例报告[J].中国当代儿科杂志,2010,12(1):17-20.
[7] 马朝,张伟,梅思斌,等.糖皮质激素联合抗甲状腺素药物治疗Graves病的Meta分析[J].中国现代应用药学,2016,33(10):1318-1323.
[8] 胡晓东,黄泽平.左旋甲状腺素治疗不同促甲状腺激素浓度老年亚临床甲状腺功能减退患者临床观察[J].临床军医杂志,2017,45(5):525-527.
[9] 刘春娟,郑艳姬.重度子痫前期合并甲状腺功能减退症孕妇甲状腺功能及妊娠结局比较[J].中南医学科学杂志,2017,45(4):397-400.
[10] 李一凡,张少霞,刘浩.伴有抑郁症状的精神分裂症患者血清甲状腺激素表达水平分析[J].检验医学与临床,2017,14(6):811-813.
[11] 王海东,吕述彦.不同TSH标准诊断的妊娠早期亚甲减及TPO-Ab阳性对妊娠的影响分析[J].现代医学,2016,44(12):1722-1726.
[12] 李静.左甲状腺素联合甲硫咪唑治疗儿童甲状腺功能亢进的疗效及安全性评价[J].现代医学,2017,45(3):430-432.
[13] 王建军,于芹.探讨FT3、FT4、TSH与T3、T4联合检测对于甲状腺功能评定的价值[J].医学信息,2015,25(23):229-229.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录