Objective: To explore the significance of follicle-stimulating hormone(FSH), luteinizing hormone(LH), estrogen(E2) and anti-mullerian hormone(AMH) in patients undergoing stripping of uterine leiomyoma. Methods: 62 cases of patients with uterine leiomyoma treated in our hospital from Jan.2014 to Jan.2017 were selected. They were divided into observation group(31 cases) and control group(31 cases) according to the different operation methods. The observation group underwent stripping of uterine leiomyoma, and the control group was given panhysterectomy. Another 31 cases of healthy volunteers were selected as blank group. The clinical data was compared among the 3 groups. Results: The operation time, intraoperative bleeding, postoperative flow, anal exhausting time and hospitalization time in observation group was lessthan that in the control group(P < 0.05). 6 months after operations, the levels of FSH and LH high to low were the control group, the observation group and the blank group from; the levels of E2 and AMH from high to low were the blank group, the observation group and the control group (P < 0.05). The rates of night sweats, hair loss, constipation, vaginal dryness and personality changes in the observation group were all lower than those in the control group(P < 0.05). Conclusions: For patients with uterine fibrods in childbearing age, the uterine fibroids stripping surgery for the ovarian endocrine function and the quality of life of the patients is less, and we should try to avoid total hysterectomy while considering the indications.