Objective: To investigate the clinical effect of cognitive function and quality of life in patients with intractable temporal lobe epilepsy after anterior temporal lobectomy. Methods: 126 patients with refractory temporal lobe epilepsy treated in our hospital from June 2013 to June 2015 were selected. Among them, 92 patients underwent anterior temporal lobectomy and 34 patients underwent non-surgical treatment. 1 months before the operation and 1 months, 1 year and 2 years after the operation, the epilepsy incidence, the cognitive function and the quality of life of the patients were compared and analyzed. Results: Before the operation, there was no significant difference of epilepsy incidence between the two groups(P>0.05). 1 months after surgery, the overall epilepsy incidence of patients in operation group was significantly lower than the non-operation group(P<0.05), and the degree of epilepsy control in operation group were significantly better than that in the non-operation group(P<0.001) especially after 1 years and 2 years of the operation. Before the operation, there was no significant difference of VIQ, PIQ, with FIQ and MQ between the two group(P>0.05). 1 months after surgery, the memory function of patients in operation group was significantly lower than that in the non-operation group(P<0.05), and no significant difference of other indexes was found between the two group(P>0.05).But one year after operation, the cognitive function of patients in operation group was significantly improved and better than that in non-operation group, the difference was statistically significant(P<0.05).The cognitive function of patients in the non-operation group had no significant improvement compared with pre operation. During 2 years of follow-up, the quality of life of patients in the operation group was significantly higher than that in the non-operation group, and the difference was statistically significant(P<0.05). Conclusion: The long-term results show that anterior temporal lobectomy can improve the cognitive function of patients with intractable temporal lobe epilepsy to a certain extent, which also can significantly control the incidence of epilepsy and improve the quality of life of patients. |
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