网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
极速脉搏波技术在年龄相关的颈动脉粥样硬化进展程度定量评估中的应用价值
作者:戴萍  王晗  李宏波  朱正球  刘牛  吴琳琳  黄辉 
单位:江苏省中医院 超声医学科, 江苏 南京 210029
关键词:极速脉搏波技术 颈动脉 年龄相关的颈动脉粥样硬化 
分类号:R445.1
出版年·卷·期(页码):2018·46·第一期(7-11)
摘要:

目的:探讨极速脉搏波(ufPWV)技术定量评估年龄相关颈动脉粥样硬化进展程度的应用价值。方法:选取健康体检者100例,21~30岁、31~40岁、41~50岁、51~60岁、61~70岁5个年龄组各20例,各年龄组男女比均为1:1。利用ufPWV技术检测每位受检者颈动脉收缩早期脉搏波速度(BS)和收缩末期脉搏波速度(ES)。取ES与BS的差值得出脉搏速度差(DPWV),计算其与脉压差(DP)的比值(DPWV/DP),进一步分析血压对脉搏波速度(PWV)的影响。结果:BS、ES在各年龄组之间差异均有统计学意义(分别P=0.000、P=0.000);相关性分析显示,BS、ES均与年龄有显著相关性(分别r=0.454,P=0.000;r=0.789,P=0.000)。DPWV及DPWV/DP在各年龄组之间差异均有统计学意义(分别P=0.000、P=0.000);DPWV及DPWV/DP与年龄均有显著相关性(分别r=0.690,P=0.000;r=0.647,P=0.000)。结论:无论血压校正与否,BS、ES均可作为评估年龄相关颈动脉粥样硬化进展程度的有效指标,且ES的价值明显优于BS。

Objective:To explore the application value of ultrafast ultrasound imagine pulse wave velocity technology(ufPWV) on quantitative evaluation of age-related carotid atherosclerosis progression.Methods:One hundred healthy subjects were selected and divided into five age groups (21-30 years old, 31-40 years old, 41-50 years old, 51-60 years old and 61-70 years old) with 20 subjects in each group. The ratio of male to female in each age group was 1:1.The ufPWV technique was used to measure the pulse wave velocity of the beginning of the systole(BS) and the end of the systole(ES). The difference value between ES and BS was calculated to obtain the difference of pulse wave velocity(DPWV),and the ratio of DPWV to the difference of pulse pressure(DP) was further analyzed to study the influence of blood pressure on pulse wave velocity(PWV). Results:ES and BS were statistically significant among the all groups(P=0.000,P=0.000,respectively). According to results of correlation analysis, BS and ESwere positively correlated with age (r=0.454,P=0.000; r=0.789, P=0.000;respectively).DPWV and DPWV/DP were statistically significant among the all groups (P=0.000,P=0.000,respectively). The results of correlation analysis showed that DPWV and DPWV/DP were significantly correlated with age (r=0.690, P=0.000; r=0.647, P=0.000,respectively). Conclusion:BS and ES can be used as a effectiveindicator of age-related carotid atherosclerosis progression no matter whether the blood pressure is corrected or not, and ES is superior to BS.

参考文献:

[1] YAMASHINA A,TOMIYAMA H.Arteriosclerosis and pulse wave velocity[J].Nihon Rinsho,2004,62:80-86.
[2] COUADE M,PERNOT M,MESSAS E,et al.Ultrafast imagine of the arterial pulse wave[J].IRBM,2011,32(2):106-108.
[3] MIRAULT T,PERNOT M,FRANK M,et al.Carotid stiffness change over the cardiac cycle by ultrafast ultrafsound imaging in healthy volunteers and vascular Ehlers-Danlos syndrome[J].J Hypertens,2015,33(9):1890-1896.
[4] 黄辉,朱正球,栾云,等.超极速超声成像脉搏波技术在早期颈动脉粥样硬化风险动态评估中的应用价值[J].东南大学学报:医学版,2017,36(1):9-13.
[5] HERMELING E,OEKS A P,WINKENS M H,et al.Noninvasive assessment of arterial stiffness should discriminate between systolic and diastolic pressure range[J].Hypertension,2010,55(1):124-130.
[6] LAURENT S,BOUTOUYRIE P.Recent advances in arterial stiffness and wave reflection in human hypertension[J].Hypertension,2007,49(6):1202-1206.
[7] PERALTA C A,ADENEY K L,SHLIPAK M G,et al.Structural and functional vascular alterations and incident hypertension in normotensive adults the multi-ethnic study of atherosclerosis[J].Am J Epidemiol,2010,171(1):63-71.
[8] ALAN S,ULGEN M S,OZTURK O,et al.Relation between coronary artery disease,risk factors and intima-media thickness of carotid artery,arterial distensibility,and stiffness index[J].Angiology,2003,54(3):261-267.
[9] WEBER T,AUER J,O'ROURKE M F,et al.Arterial stiffness,wave reflection,and the risk of coronary artery disease[J].Circulation,2004,109(2):184-189.
[10] 张维忠.动脉弹性功能的临床研究的现状及意义[J].中华心血管杂志,2003,31(4):243-244.
[11] MESSAS E,PERNOT M,COUADE M.Arterial wall elasticity:State of the art and future prospects[J].Diagn Interv Imaging,2013,94(5):561-569.
[12] HERMELING E,VERMEERSCH S J,RIETZSCHEL E R,et al.The change in arterial stiffness over the cardiac cycle rather than diastolic stiffness is independently associated with left ventricular mass index in healthy middle-aged individuals[J].J Hypertens,2012,30(2):396-402.
[13] 王凤娣,黄英,朱玉兰,等.影响脉搏波传导速度的临床多因素分析[J].湖南医学,2008,19(9):3-5.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 232443 位访问者


 ©《现代医学》编辑部
联系电话:025-83272479;83272481
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541