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脂蛋白(a)与缺血性卒中相关性研究进展
作者:倪淑婷1 2  张志珺2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 神经内科, 江苏 南京 210009
关键词:脂蛋白(a) 载脂蛋白(a) 缺血性卒中 治疗 综述 
分类号:R743.3
出版年·卷·期(页码):2017·36·第十二期(1860-1864)
摘要:

近年来有研究发现高脂蛋白(a)血症与缺血性卒中相关。脂蛋白(a)是一种同时含有载脂蛋白(a)、载脂蛋白B两种组分的脂蛋白,其血清浓度在人群中呈高度偏态分布,主要受遗传因素控制,与血清型密切相关。其导致缺血性卒中的可能机制包括促动脉粥样硬化和影响纤溶功能。对于高脂蛋白(a)血症,缓释烟酸联合他汀的临床获益受到质疑,血浆置换能使患者获益,PCSK9单克隆抗体、靶向载脂蛋白(a)的反义寡核苷酸治疗能显著降低血清脂蛋白(a)水平,部分药物已获得上市批准,但药物的安全性及临床获益仍待进一步的研究证实。本文作者拟对近年来脂蛋白(a)与缺血性卒中相关性及高脂蛋白(a)血症治疗研究的新进展进行综述。

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