同天分剂量服用聚乙二醇电解质溶液方案在肠道准备中的效果观察-现代医学

同天分剂量服用聚乙二醇电解质溶液方案在肠道准备中的效果观察

单位：安徽医科大学第三附属医院消化内科, 安徽合肥 230000

分类号：R574

出版年·卷·期（页码）：2017·36·第十二期（1805-1808）

摘要：

目的：探讨同天分剂量服用聚乙二醇电解质溶液（PEG-ES）方案在肠道准备中的效果。方法：采用随机、单盲、前瞻性研究方法，共纳入210例门诊拟行肠镜检查的患者并随机分为三组，三组患者给予不同时间间隔的服药方案，其中A组采用连续服药方案；B、C两组分别采用两次服药时间间隔为3 h和5 h的分剂量方案。肠道准备的质量评估参照Boston肠道准备评分标准（BBPS），同时设计调查问卷获取患者服药过程中的相关情况。结果：三组BBPS总评分及全结肠息肉发现率无统计学差异（P>0.05）；C组右半结肠清洁度优于A组，C组中息肉在右半结肠的检出率及排便次数大于A组（P<0.05）；B、C两组中不良反应发生率均少于A组，且再次准备意愿大于A组（P<0.05）。结论：检查当天做肠道准备时，分剂量服用PEG-ES方案可减少患者不良反应发生率；当服药间隔达5 h时，可增加右半结肠的清洁度，提高右半结肠的息肉检出率，在高度怀疑患者右半结肠病变时可做为首选。

Objective: To investigate the effect daily split-doze ofpolyethylene glycol electrolyte solution(PEG-ES) regimen in bowel preparation.Methods: Single blind prospective randomized trial was performed. A total of 210 outpatients undergoing colonoscopy were enrolled and randomized into three groups; subjects in group A used the continuous administration regimen; Subjects in group B and C use the split-doze regimen at an interval 3 h and 5 h respectively. The quality of bowel preparation was assessed on the basis of the Boston bowel preparation scale(BBPS). At the same time, a questionnaire was designed to obtain the relevant situation in the course of administration.Results: There was no significant difference in the total score of BBPS and total adenoma detection rates(P>0.05) between the three groups. The cleanliness of right colon in group C was better than that of group A,the adenoma detection rates in right colon and the times of total defecation in group C were greater than group A(P<0.05).The incidence of adverse reactions in group B and C were both less than group A, and the willingness of repeated preparation in group B and C was greater than group A(P<0.05).Conclusion: The split-doze of PEG-ES regimen can reduce the adverse reaction rates on the day of colonoscopy. It can enhance the cleanliness and increase the adenoma detection rates of the right colon at an interval of 5 hours. Accordingly this regimen could be used as the first choice for the patients who are highly suspected with lesions of the right colon.

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