胸腔镜肺叶切除术治疗非小细胞肺癌术后炎症反应临床分析-现代医学

胸腔镜肺叶切除术治疗非小细胞肺癌术后炎症反应临床分析

单位：南京市胸科医院心胸外科, 江苏南京 210000

分类号：R734.2

出版年·卷·期（页码）：2017·36·第十二期（1801-1804）

摘要：

目的：分别采用传统开胸肺叶切除术及电视胸腔镜肺叶切除术用于治疗非小细胞肺癌（NSCLC），比较两种肺叶切除术用于治疗NSCLC的效果及术后炎症反应状态的变化。方法：选择我院收治的NSCLC患者98例，随机分为研究组（n=49）和对照组（n=49）。对照组实施传统开胸肺叶切除术，研究组接受电视胸腔镜肺叶切除术，比较患者炎症反应状态的变化。结果：研究组的术中出血量、胸腔引流时间、住院时间均明显优于对照组，术后的IL-6、IL-8、CRP、TNF、PCT水平明显高于对照组，术后3天的CD8⁺ T、CD4⁺ T、CD4⁺ T/CD8⁺ T、NK好于对照组，差异均有统计学意义（P<0.05）。结论：采用胸腔镜肺叶切除术能明显降低非小细胞癌患者的创伤，减轻患者的炎症反应状态，改善患者的预后水平。

Objective: To investigate the video-assisted thoracoscopic surgery(VATS) for the treatment of non-small cell lung cancer(NSCLC) and the changes in inflammatory response after operation.Methods: In our hospital, 98 patients with NSCLC were selected and divided into two groups randomly:the study group(n=49) and the control group(n=49).The control group received traditional thoracotomy lobectomy, and the study group received video-assisted thoracoscopic lobectomy. Inflammatory response was compared between the patients.Results: The intraoperative blood loss, thoracic drainage time and hospitalization time in the study group were significantly better than those in the control group. The levels of IL-6, IL-8, CRP, TNF and PCT after operation were significantly higher than those of the control group. CD8⁺ T, CD4⁺ T, CD4⁺ T/CD8⁺ T and NK in the 3 days after operation were better than those in the control group. The differences were statistically significant(P<0.05).Conclusion: The VATS can significantly reducethe trauma and inflammation of the patients, improve the prognosis of the patients.

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