[1] JEMAL A,SIEGEL R,WARD E,et al.Cancer statistics,2007[J].CA Cancer J Clin,2007,57(1):43-66.
[2] BAYRAKTAR S,ROCHA-LIMA C M.Advanced or metastatic pancreatic cancer:molecular targeted therapies[J].Mt Sinai J Med,2010,77(6):606-619.
[3] GERKEN T,GIRARD C A,TUNG Y C,et al.The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase[J].Science,2007,318(5855):1469-1472.
[4] HAN Z,NIU T,CHANG J,et al.Crystal structure of the FTO protein reveals basis for its substrate specificity[J].Nature 2010,464(7292):1205-1209.
[5] JIA G,FU Y,ZHAO X,et al.N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO[J].Nat Chem Biol,2011,7(12):885-887.
[6] FRAYLING T M,TIMPSON N J,WEEDON M N,et al.A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity[J].Science,2007,316(8526):889-894.
[7] FISCHER J,KOCH L,EMMERLING C,et al.Inactivation of the Fto gene protects from obesity[J].Nature,2009,458(7240):894-898.
[8] GAO X,SHIN Y H,LI M,et al.The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice[J].PloS one,2010,5(11):e14005.
[9] FU Y,DOMINISSINI D,RECHAVI G,et al.Gene expression regulation mediated through reversible m(6)A RNA methylation[J].Nat Rev Genet,2014,15(5):293-306.
[10] HE C.Grand challenge commentary:RNA epigenetics?[J].Nat Chem Biol,2010,6(12):863-865.
[11] WEI C M,GERSHOWITZ A,MOSS B.Methylated nucleotides block 5' terminus of HeLa cell messenger RNA[J].Cell,1975,4(4):379-386.
[12] DOMINISSINI D,MOSHITCH-MOSHKOVITZ S,SCHWARTZ S,et al.Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq[J].Nature,2012,485(7397):201-206.
[13] MEYER K D,SALETORE Y,ZUMBO P,et al.Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons[J].Cell,2012,149(7):1635-1646.
[14] WANG X,LU Z,GOMEZ A,et al.N6-methyladenosine-dependent regulation of messenger RNA stability[J].Nature,2014,505(7481):117-120.
[15] HUNTZINGER E,IZAURRALDE E.Gene silencing by microRNAs:contributions of translational repression and mRNA decay[J].Nat Rev Genet,2011,12(2):99-110.
[16] ESQUELA-KERSCHER A,SLACK F J.Oncomirs-microRNAs with a role in cancer[J].Nat Rev Genet,2006,6(4):259-269.
[17] STAHLHUT ESPINOSA C E,SLACK F J.The role of microRNAs in cancer[J].Yale J Biol Med,2006,79(3-4):131-140. |