Objective: To observe the clinical effects of intranasal dexmedetomidine in pediatric tonsillectomy.Methods: Thirty children undergoing tonsillectomy were randomly divided into dexmedetomidine 1.0μg·kg-1 group(D group) and normal saline group(NS group). They received intranasal dexmedetomidine 1.0 μg·kg-1 or normal saline 30 munites before anesthesia induction. The sedation score of placement of Ⅳ cannula and parental separation were recorded,the agitation score at tracheal extubation and at five minutes after PACU were recorded too. The changes of HR,MAP,RR,SpO2 were recorded before intranasal administration(T0, baseline), 30 minutes after intranasal administration(T1), at the time of intubation (T2), at the time of extubation (T3) and 5 minutes after extubation (T4).Results: The HR in group D at T1-T4 were lower than those at T0. The HR in group NS at T2,T3 were higher than those at T0. The HR in group D were lower than those in group NS at T1-T4,and there were statistically significant(P<0.05).The sedation score at parental separation,the agitation score at tracheal extubation and at five minutes after PACU were different between the two groups,and there were statistically significant(P<0.05)Conclusion: Intranasal dexmedetomidine before anesthesia induction may provide a safe and good sedation effect for chidren undergoing tonsillectomy,and can prevent emergence agitation. |