Objective:To study the effect of Dizhuohuatan decoction in pulmonary function and serum inflammatory factors of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) patients. Methods:80 AECOPD patients were randomized into western medicine group and Dizhuohuatan decoction group, 40 cases in each group. Western medicine treatment group received routine western medicine, dizhuohuatan decoction treated with western medicine combined dizhuohuatan decoction. Pulmonary function, serum inflammatory factor, life quality and adverse reactions during the treatment were recorded and compared within groups. Results:Before treatment, forced expiratory volume in one second(FEV1), FEV1% predictive value between the two groups, interleukin-8(IL-8), procalcitonin (PCT), high-sensitive C-reactive protein (hs-CRP) and the quality of life scores had no statistical differences(P>0.05). After treatment, compared with the western medicine group(P < 0.05), the FEV1, FEV1% and the quality of life scores had increased, IL-8, PCT and hs-CRP had decreased(P < 0.05) in the Dizhuohuatan decoction group. The incidence of adverse reactions in the two groups had no statistically significant differences(P>0.05). Conclusion:Dizhuohuatan decoction can effectively improve lung function in AECOPD by decreasing serum inflammatory cytokines. |
[1] 姜艳平,程改存,赵云峰,等. COPD稳定期患者噻托溴铵联合沙美特罗/氟替卡松治疗效果的CAT量表评估[J]. 东南大学学报(医学版),2012,31(3):294-298.
[2] 马红霞,罗建江,张茜.慢性阻塞性肺疾病患者营养不良的脾胃论治临床研究[J].中华医院感染学杂志,2014,24(14):3497-3499.
[3] 包蒙,林勇. 高分辨率CT与慢性阻塞性肺疾病表型的关系[J]. 东南大学学报(医学版),2012,31(3):385-387.
[4] 刘开林.慢性阻塞性肺病并发急性呼吸衰竭的危险因素分析[J].内科,2014,9(3):278-280,286.
[5] 洪原城,黄种杰,黄鑫成,等.慢性阻塞性肺疾病伴意识障碍病情程度与患者动脉血气参数关系的临床研究[J].临床肺科杂志,2015,3(1):453-455.
[6] ARMANNSDOTTIR K R,JONSDOTTIR H.The relationships between smoking and anxiety and depression in people with COPD-Implications for smoking cessation treatment for people with COPD[J]. Eur Respir J,2014,44(Suppl 58):1409.
[7] COLLINS P F,ELIA M,STRATTON R J.Nutritional support and functional capacity in chronic obstructive pulmonary disease:a systematic review and meta-analysis[J].Respirology,2013, 18(4):616-629.
[8] WILCHESKY M, ERNST P, BROPHY J M,et al. Bronchodilator use and the risk of arrhythmia in COPD:Part 1:Saskatchewan Cohort Study[J].Chest,2012,142(2):298-304.
[9] PEPIN J L, COCKCROFT J R, MIDWINTER D,et al. Long-acting bronchodilators and arterial stiffness in patients with COPD:a comparison of fluticasone furoate/vilanterol with tiotropium[J].Chest,2014,146(6):1521-1530.
[10] JONES R C M,PRICE D,RYAN D, et al. Opportunities to diagnose chronic obstructive pulmonary disease in routine care in the UK:a retrospective study of a clinical cohort[J].Lancet Respir Med,2014,2(4):267-276.
[11] WANG T Y, LO Y L,CHOU P C,et al. Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease[J]. Int J Chron Obstruct Pulmon Dis,2015,29(10):231-237.
[12] 倪海滨,刘克琴,张晓震.血府逐瘀汤对慢性阻塞性肺疾病急性加重合并肺动脉高压患者肺部感染控制窗的影响[J].中国中医急症,2016,25(3):405-407.
[13] HANNINK J D, van HEES H W,DEKHUIJZEN P N, et al.Non-invasive ventilation abolishes the IL-6 response to exercise in muscle-wasted COPD patients:a pilot study[J].Scand J Med Sci Sports,2014,24(1):136-143.
[14] BHATT S P,PETERSON M W,WILSON J S,et al. Noninvasive positive pressure ventilation in subjects with stable COPD:a randomized trial[J].Int J Chron Obstruct Pulmon Dis,2013,8(1):581-589.
[15] 洪辉华,王真,杨珺超,等.益气健脾法治疗慢性阻塞性肺疾病稳定期肺脾气虚型患者的多中心临床研究[J].中华中医药杂志,2014,29(4):1153-1156.
[16] 袁乐东,黎林盛,蒙斌. 苇茎汤加减治疗慢性阻塞性肺疾病急性加重期患者临床疗效及其对TNFα、IL-8的影响[J]. 哈尔滨医药,2017,37(2):177-178.
[17] 钭南霖,张剑,邓俊义,等. 中西医结合治疗重症肺炎患者临床疗效观察及对患者炎症因子水平的影响[J]. 中国中医急症,2016,25(2):363-365.
[18] 王俊,刘巧丽,周柒媛,等. 苇茎汤加减配合西药治疗老年肺炎患者的疗效及其对生活质量的影响[J/OL]. 中国社区医师,2015,31(33):76-77. |
