Objective:To comparison of continuous veno-venous hemofiltration(CVVH) combined with intermittent hemodialysis(IHD) and hemoperfusion in the treatment of acute renal failure(ARF) caused by bee stings. Methods:Seventy eight ARF patients caused by bee stings collected from 2010 to 2016 in our hospital. They were randomly divided into two groups. CVVH/IHD group (n=40) was treated with CVVH+IHD. HP/IHD group (n=38) was treated with HP+IHD. Scr,BUN, β2-microglobulin (β2-MG) and so on in the two groups were observed before and after treatment and the number of peripheral white blood cells were observed. Platelet count, erythrocyte count, hemoglobin concentration, total protein, C-reactive protein, and electrolyte (K+, Cl-) were also studied. The total effective rate, mean duration of oliguria and average hospital stay were compared. Results:There was no significant difference in clinical data between the two groups(P>0.05). After treatment, all the patients were improved(P<0.05). The levels of BUN and Scr inCVVH/IHD group were significantly higher than those in HP/IHD group(P<0.05), while the changes of β2-MG, K+ and hs-CRP were not significantly different between the two groups(P>0.05). The total effective rate of HP/IHD group was lower than that of CVVH+IHD group, and the duration of urinary catheterization and hospital stay were higher than those of CVVH+IHD group(P<0.05). The incidence of adverse events in the HP/IHD group was 2.63% (1/38) and the incidence of adverse events in the CVVH/IHD group was 2.50% (1/40). Conclusion:CVVH combined with IHD can effectively remove the toxic substances in the body, significantly improve the clinical efficacy of renal function, increase the patient's curative rate without serious adverse reactions. |
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