HIF-1α、CRP在溃疡性结肠炎患者血清中表达的意义-现代医学

HIF-1α、CRP在溃疡性结肠炎患者血清中表达的意义

单位：北京航天总医院消化内科, 北京 100076

分类号：R574.62

出版年·卷·期（页码）：2017·36·第十期（1468-1471）

摘要：

目的：分析低氧诱导因子-1α（HIF-1α）、C-反应蛋白（CRP）在溃疡性结肠炎患者血清中表达的意义。方法：选取我院90例溃疡性结肠炎患者，其中69例活动期者为活动组，21例缓解期者为缓解组，另选40例体检健康者为对照组。采用ELISA法测定3组研究对象血清HIF-1α、CRP水平，同时对活动组患者进行肠镜检查，并对其病情严重程度进行评估。结果：活动组血清HIF-1α、CRP水平均高于缓解组（t=2.89、3.12，均P<0.05），且均高于对照组（t=2.96、2.76，均P<0.05）；而缓解组血清HIF-1α、CRP水平较对照组均无明显差异（t=0.74、0.35，均P>0.05）。血清HIF-1α、CRP水平与活动期溃疡性结肠炎患者病情严重程度（r=0.71、0.63）、内镜表现分级（r=0.76、0.69）均存在显著相关性（均P<0.05）。结论：血清HIF-1α、CRP表达与溃疡性结肠炎患者病情严重程度及内镜表现分级密切相关，提示HIF-1α、CRP均可能在溃疡性结肠炎发生、发展过程中发挥显著作用，二者联合检测可作为评估溃疡性结肠炎患者病情严重程度的重要指标。

Objective: To analyze the significance of serum hypoxia inducible factor-1α(HIF-1α) and C-reactive protein(CRP) expression in patients with ulcerative colitis. Methods: Ninety cases of ulcerative colitis patients in our hospital were selected as research subjects, of whom 69 patients in active stage and 21 patients in remission stage were respectively divided into active group and relief group. Another 40 healthy controls were used as control group. The levels of serum HIF-1α and CRP in the three groups were measured by ELISA. Colonoscopy was performed on the active group and the severity of the disease was assessed. Results: The levels of serum HIF-1α and CRP in the active group were higher than those in the relief group(t=2.89, 3.12, P<0.05) and those in the control group(t=2.96, 2.76, P<0.05), while the levels ofserumHIF-1α and CRP in the relief group showed no significant differences in comparison with the control group(t=0.74, 0.35, P>0.05). The serum levels of HIF-1α and CRP were significantly correlated with the severity of the disease(r=0.71, 0.63) and endoscopic grading(r=0.76,0.69) in patients with ulcerative colitis(P<0.05). Conclusion: The expression ofserum HIF-1α and CRP is closely related to the severity and endoscopic grading of ulcerative colitis, suggesting that HIF-1α and CRP may play a significant role in the development and progression of ulcerative colitis. Combined detection of HIF-1α and CRP can be used as important indexes to evaluate the severity of ulcerative colitis.

参考文献：

[1] BEYAZIT Y,SAYILIR A,TANOGLU A,et al.Plasma thrombin-activatable fibrinolysis inhibitor levels correlate with the disease activity of ulcerative colitis[J].Intern Med,2016,55(14):1831-1836.
[2] LYNCH R W,CHURCHHOUSE A M,PROTHEROE A,et al.Predicting outcome in acute severe ulcerative colitis:comparison of the Travis and Ho scores using UK IBD audit data[J].Aliment Pharmacol Ther,2016,43(11):1132-1141.
[3] ÖNAL I K,BEYAZIT Y,SENER B,et al.The value of fecal calprotectin as a marker of intestinal inflammation in patients with ulcerative colitis[J].Turk J Gastroenterol,2012,23(5):509-514.
[4] 许春梅,刘波,董卫国.溃疡性结肠炎患者血清低氧诱导因子-1α的检测及意义[J].临床消化病杂志,2014,26(2):93-95.
[5] de CASSAN C,SAVARINO E,MARSON P,et al.Granulo-monocyto apheresis is more effective in mild ulcerative colitis than in moderate to severe disease[J].World J Gastroenterol,2014,20(45):17155-17162.
[6] LANDY J,WAHED M,PEAKE S T,et al.Oral tacrolimus as maintenance therapy for refractory ulcerative colitis-an analysis of outcomes in two London tertiary centres[J].J Crohns Colitis,2013,7(11):e516-521.
[7] 朱建斌,杜锦辉,关敬之,等.低氧诱导因子-1α在溃疡性结肠炎患者血清和结肠黏膜中的表达及意义[J].山西医药杂志,2017,46(3):296-297.
[8] 黄素娴,林建姣,袁小刚.溃疡性结肠炎患者血清低氧诱导因子-1α、CRP的含量及其临床意义[J].海南医学,2015,26(23):3445-3447.
[9] 郑丽萍.IL-8、TNF-α、高敏C反应蛋白检测在溃疡性结肠炎诊断中的临床意义[J].社区医学杂志,2012,10(20):53-54.
[10] CABRERA-ACOSTA G A,MILKE-GARCIA M P,RAMIREZ-IGLESIAS M T,et al.Deficient lactose digestion and intolerance in a group of patients with chronic nonspecific ulcerative colitis:a controlled,double-blind,cross-over clinical trial[J].Rev Gastroenterol Mex,2012,77(1):26-30.
[11] IYER V H,AUGUSTINE J,PULIMOOD A B,et al.Correlation between coinfection with parasites,cytomegalovirus,and Clostridium difficile and disease severity in patients with ulcerative colitis[J].Indian J Gastroenterol,2013,32(2):115-118.
[12] KOFLA-D UBACZ A,MATUSIEWICZ M,KRZESIEK E,et al.Metalloproteinase-3 and -9 as novel markers in the evaluation of ulcerative colitis activity in children[J].Adv Clin Exp Med,2014,23(1):103-110.
[13] CELIKBILEK M,DOGAN S,OZBAKLR O,et al.Neutrophil-lymphocyte ratio as a predictor of disease severity in ulcerative colitis[J].J Clin Lab Anal,2013,27(1):72-76.
[14] 张小艳,白苇,帖军,等.HIF-1α和COX-2在溃疡性结肠炎患者外周血及黏膜组织中表达及意义[J].现代生物医学进展,2015,15(33):6550-6554,6566.
[15] 张伟,杨银利,吴洁琼,等.溃疡性结肠炎患者血清肿瘤坏死因子-α与C反应蛋白水平变化及意义[J].中华实用诊断与治疗杂志,2013,27(7):681-682.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录