胰岛素强化治疗对初诊2型糖尿病患者胰岛β细胞功能及胰岛素抵抗的影响-现代医学

胰岛素强化治疗对初诊2型糖尿病患者胰岛β细胞功能及胰岛素抵抗的影响

单位：陕西省榆林市第二医院内分泌科, 陕西榆林 719000

分类号：R587.1

出版年·卷·期（页码）：2017·36·第十期（1462-1464）

摘要：

目的：探讨胰岛素强化治疗初诊2型糖尿病的临床疗效以及对胰岛β细胞功能的影响。方法：选择在我院接受治疗的100例初诊2型糖尿病患者，采用计算机单盲分组法随机分为对照组和观察组各50例，对照组接受口服二甲双胍治疗，观察组接受胰岛素强化治疗，比较两组患者的血糖情况、胰岛素抵抗指数、胰岛β细胞功能指数、低血糖发生率。结果：治疗后观察组的空腹血糖、餐后2 h血糖、糖化血红蛋白均明显低于治疗前（P<0.05）和对照组治疗后（P<0.05）；治疗后两组胰岛素抵抗指数均明显降低（P<0.05），胰岛β细胞功能指数明显增高（P<0.05），观察组较对照组胰岛素抵抗指数更低、胰岛β细胞功能指数更高（P<0.05）；观察组低血糖发生率较对照组差异无统计学意义（P>0.05）。结论：针对初诊2型糖尿病患者采用胰岛素强化治疗，可有效降低患者的血糖水平，减轻其机体胰岛素抵抗，有利于修复胰岛β细胞功能，且安全可靠。

Objective: To study and explore the clinical efficacy of insulin intensive therapy on newly diagnosed type 2 diabetes mellitus and its effect on pancreatic β-cell function.Methods: One hundred patients with newly diagnosed type 2 diabetes treated in our hospital were included in this study. By using computer single-blind grouping method the patients were randomly divided into control group and observation group with 50 in each group. The control group was treated with oral metformin, while the observation group was treated with insulin intensive therapy. The blood glucose, insulin resistance index, islet β cell function index and hypoglycemia incidence were compared between the two groups. Results: After treatment, the fasting blood glucose, 2 h postprandial blood glucose and glycosylated hemoglobin in the observation group were significantly lower than those before treatment(P<0.05) and those in the control group after treatment (P<0.05). The insulin resistance index of the two groups decreased obviously(P<0.05), and the islet β cell function index was significantly increased(P<0.05). After treatment insulin resistance index in the observation group was significantly lower than that in the control group and β cell function index was significantly higher, the difference being statistically significant(P<0.05).Conclusion: The intensive insulin treatment can improve the blood glucose level and reduce the insulin resistance in patients with type 2 diabetes mellitus. It is helpful to repair the islet β cell function and is safe and reliable.

参考文献：

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