Objective: To analyze the influence of total parathyroidectomy on coronary artery calcification and left ventricular hypertrophy in uremia patients with secondary hyperparathyroidism(SHPT).Methods: Thirty-six cases of hemodialysis patients with SHPT who had undergone total parathyroidectomy were included in the study. The preoperative, postoperative and follow-up serum parathyroid hormone, serum calcium, serum phosphorus, alkaline phosphatase, coronary artery calcium score(CAC), end-diastolic diameters of left ventricular posterior wall thickness(LVPWT), left ventricular end-diastolic dimension(LVEDD) and interventricular septum thickness(IVST) were statistically analyzed. Results: Compared with preoperation, serum calcium, serum phosphorus, the calcium-phosphorus product, parathyroid hormone, bone-specific alkaline phosphatase, and CAC were decreased significantly(P<0.01).6 months and 12 months after operation with statistically significant difference, and LVPWT and LVDD were also decreased significantly(all P<0.05).Conclusion: Total parathyroidectomy can effectively control the progress of coronary artery calcification, improve the left ventricular hypertrophy and reduce the risk of cardiovascular death in uremic patients with secondary hyperparathyroidism(SHPT). |
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