网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
多种血清肿瘤标志物联合检测诊断非小细胞肺癌的临床价值
作者:卢兴兵  李勤  石佳  刘波  杨舒羽  陈娟  曾素根  谢轶 
单位:四川大学华西医院 实验医学科, 四川 成都 610041
关键词:非小细胞肺癌 肿瘤标志物 联合检测 
分类号:R734.2
出版年·卷·期(页码):2017·36·第十期(1417-1421)
摘要:

目的:探讨血清肿瘤标志物神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(Cyfra21-1)、糖类抗原199(CA199)、癌胚抗原(CEA)和乳酸脱氢酶(LDH)联合检测在诊断非小细胞肺癌(NSCLC)中的临床价值。方法:通过酶法和电化学发光方法分别检测283例NSCLC、192例肺良性病及207健康体检者的NSE、Cyfra21-1、CA199、CEA和LDH。结果:NSCLC组的NSE、Cyfra21-1、CA199、CEA和LDH 5项结果均高于肺良性病和健康体检者(P<0.05);在NSCLC病理分型中,CEA在腺癌者中表达水平明显高于鳞癌者,鳞癌者的Cyfra21-1含量高于腺癌者(P<0.05);TNM分期T1/T2期的NSE、Cyfra21-1、CEA和LDH 4种肿瘤标志物表达水平均明显低于T3/T4期,临床分期Ⅰ/Ⅱ期的NSE、Cyfra21-1、CA199、CEA和LDH含量均显著低于Ⅲ/Ⅳ期(P<0.05);联合检测的阳性结果和敏感度均显著高于单项检测(P<0.05);Cyfra21-1和CEA对NSCLC诊断效能最高,CEA和Cyfra21-1分别对肺腺癌和肺鳞癌诊断效能最高。结论:NSE、Cyfra21-1、CA199、CEA和LDH 5种肿瘤标志物在NSCLC患者中异常高表达,且与NSCLC的临床分期和TNM分期呈正相关,联合检测能提高NSCLC的诊断效能,显著提高诊断灵敏度和特异性,对NSCLC的早期诊断、治疗监测和预后判断具有重要的参考价值。

Objective: To evaluate the clinical value of NSE, CYfra21-1, CA199, CEA and serum lactate dehydrogenase(LDH) in the auxiliary diagnosis of NSCLC. Methods: The levels of of the five tumor markers were detected in 283 cases of NSCLC by using electrochemical luminescence and enzymatic methods, of whom 192 cases were of benign lung disease and 207 individuals of healthy physical examination. Results: The levels of the serum tumor markers from NSCLC group were significantly higher than those from lung benign cases and individuals of healthy physical examination(P<0.05). The expression levels of CEA in adenocarcinoma were significantly higher than those of squamous cell carcinoma, and the content of Cyfra21-1 in squamous cell carcinoma was higher than that of adenocarcinoma(P<0.05). The levels of NSE, Cyfra21-1, CEA and LDH of NSCLC group in stage T1/T2 were lower than those in T3/T4, and the levels of NSE, Cyfra21-1, CA199, CEA and LDH of NSCLC group in the Ⅲ/Ⅳ stage were higher than those in the Ⅰ/Ⅱ stage. The sensitivity and accuracy of combined detection were significantly higher than those of single assay. Cyfra21-1 and CEA had the highest diagnostic efficacy for NSCLC, CEA had the highest diagnostic efficacy for adenocarcinoma and Cyfra21-1 had the highest diagnostic efficacy for squamous cell carcinoma of the lung. Conclusion: The five kinds of serum tumor markers are highly expressed in patients with NSCLC and significantly associated with the clinical stage and TNM classification of NSCLC. Combined detection of them can significantly improve the sensitivity and specificity of diagnosis, and has important reference value for the early diagnosis, treatment monitoring and prognosis judgment of NSCLC.

参考文献:

[1] 李健,郑琳,戚永超,等.完全与杂交式胸腔镜肺叶切除治疗早期非小细胞肺癌的疗效比较[J].现代医学,2017,45(2):234-238.
[2] XU L M,LI L Q,LI J,et al.Overexpression of miR-1260b in non-small cell lung cancer is associated with lymph node metastasis[J].Aging Dis,2015,6(6):478-485.
[3] KAUL D,ANGELIDIS A,BUDACH V,et al.Prognostic indices in stereotactic radiotherapy of brain metastases of non-small cell lung cancer[J].Radiation Oncology,2015,10(1):244.
[4] 周婉婉,梁冰,王效静,等.非小细胞肺癌患者外周血hTERT mRNA水平检测的临床意义[J].东南大学学报:医学版,2017,36(2):217-221.
[5] 尹竺晟,戈伟,罗卫.肿瘤标志物在非小细胞肺癌患者诊断中的价值[J].中国医药导报,2016,13(23):102-105.
[6] 曹青梅.血清癌胚抗原与溶血磷脂酸联合检测在非小细胞肺癌诊断中的应用价值[J].检验医学与临床,2016,13(18):2579-2581.
[7] HOU J M,KREBS M G,LANCASHIRE L,et al.Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer[J].J Clin Oncol,2012,30(5):525-532.
[8] 张智慧,吴希兰,应建明,等.细针吸取细胞学标本检测非小细胞肺癌EGFR、KRAS突变的探讨[J].中国肺癌杂志,2015,18(4):199-205.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 729337 位访问者


 ©《现代医学》编辑部
联系电话:025-83272481;83272479
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541