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腹膜透析相关性腹膜纤维化的机制
作者:李归雁  张莉 
单位:南京医科大学第一附属医院 肾内科, 江苏 南京 210029
关键词:腹膜纤维化 上皮细胞-间充质转变 转化生长因子-β Smad依赖通路 Smad非依赖通路 
分类号:R692
出版年·卷·期(页码):2017·36·第八期(1181-1186)
摘要:

腹膜透析是终末期肾病的一种有效的替代治疗。腹膜透析中多种因素可引起腹膜上皮细胞-间充质转变(EMT)和腹膜炎症,进而导致腹膜结构和功能的改变,最终引起腹膜纤维化。研究表明多种分子机制参与腹膜纤维化过程,其中转化生长因子-β(TGF-β)发挥着重要的作用,TGF-β可以通过Smad依赖和Smad非依赖通路参与多种促纤维化事件,其中包括EMT。本文将针对近年来一些关于腹膜纤维化进展的分子机制进行总结。

Peritoneal dialysis is an attractive treatment for patients with end-stage kidney disease (ESKD). However, a variety of factors in peritoneal dialysis can cause peritoneal epithelial-mesenchymal transition (EMT)and peritoneal inflammation, which can lead to the development of functional and structural alterations of the peritoneal membrane, and ultimately lead to peritoneal fibrosis. Studies show that several molecular mechanisms are involved in the process of peritoneal fibrosis, in which transforming growth factor β(TGF-β) plays an important role. TGF-β can participate in a variety of fibrotic events through Smad-dependent and Smad-independent pathways, including EMT. This review is aiming to summarize the mechanisms of peritoneal fibrosis.

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