519名体检偏头痛患者食物不耐受结果分析-现代医学

519名体检偏头痛患者食物不耐受结果分析

单位：哈尔滨医科大学附属第一医院体检会诊中心, 黑龙江哈尔滨 150001

分类号：R742

出版年·卷·期（页码）：2017·36·第八期（1158-1160）

摘要：

目的：分析体检偏头痛患者食物不耐受检测结果。方法：参与体检的519名偏头痛患者及对照组462人进行14种食物不耐受检测，通过酶联免疫法检测血清14种食物抗原的IgG抗体，根据吸光度及标准曲线计算IgG抗体浓度，并进行分级。结果：偏头痛组食物特异性IgG抗体阳性率（58.6%）高于对照组（21.2%）；偏头痛组食物特异性IgG抗体阳性率位于前7位的食物分别为：鸡蛋、牛奶、鳕鱼、虾、牛肉、大豆、小麦，这7种食物特异性IgG抗体阳性率偏头痛组大于对照组；女性偏头痛者食物特异性IgG抗体总阳性率及40岁以下年龄组阳性率高于男性，女性随年龄段增加阳性率下降，差异有统计学意义（P<0.05）。结论：食物不耐受检测对偏头痛研究有重要意义，是健康管理工作的重点。

Objective: To analyze food intolerance of migraine patients from medical examination.Methods: The level of food specific IgG antibodies in serum from 519 migraine patients and 462 controls were detected by enzyme-linked immunoassay. Results: The food specific IgG antibodies positive rate of migraine patients was significantly higher than that of the control group.(21.2%);The top seven foods with positive specific IgG antibody in Migraine food group were:eggs, Cow's milk, codfish, shrimp, beef, beans, wheat, which were higher than those of the control group; Among the migraine patients, the positive rates of food specific IgG antibodies of the female and those younger than 40 years-old were higher than the rates of the control group, the rate of female migraine patients declined with age increasing, the difference was statistically significant(P<0.05).Conclusion: Food intolerance has important implications for researches on migraine and plays an important role in management of the health.

参考文献：

[1] ZENG Q,DONG S Y,WU L X,et al.Variable food-specific IgG antibody levels in healthy and symptomatic Chinese adults[J].PloS One,2013,8(1):e53612.
[2] INTERNATIONAL HEADACHE SOCIETY.The international classification of headache disorders.2^nd ed.1^st revision[J].Cephalagia,2005,25(4):460-465.
[3] MEHLE M E.Allergy and migraine:is there a connection?[J].Curr Opin Otolaryngol Head Neck Surg,2008,16(3):265-269.
[4] ARROYAVE HERNANDEZ C M,ECHAVARRIA P M,HERNANDEZ MONTIEL H L.Food allergy mediated by IgG antibodies associated with migraine in adults[J].Rev Alerg Mex,2007,54(5):162-168.
[5] LONGONI M,FERRARESE C.Inflammation and excitotoxicity:role in migraine pathogenesis[J].Neurol Sci,2006,27(2):107-110.
[6] ALPAY K,ERTAS M,ORHAN E K,et al.Diet restriction in migraine,based on IgG against foods:A clinical double-blind,randomised,cross-over trial[J].Cephalalgia,2010,30(7):829-837.
[7] FINOCCHI C,SIVORI G.Food as trigger and aggravating factor of migraine[J].Neurol Sci,2012,33(1):77-80.
[8] 黄建,贺晓恒,李敏.广州市1059例14种食物不耐受检测结果分析[J].中华健康管理学杂志,2009,3(1):33-35.
[9] MITCHELL N,HEWITT CE,JAYAKODY S,et al.Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches[J].Nutr,2011,11(10):85.
[10] PAVLOVIC J M,ALLSHOUSE A A,SANTORO N F,et al.Sex hormones in women with and without migraine:Evidence of migraine-specific hormone profiles[J].Neurology,2016,87(1):49-56.
[11] 赵思文,陈惠芳,邹泽红,等.食物不耐受及食物过敏与肠易激综合征的临床研究[J].东南大学学报:医学版,2016,35(3):342-346.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录